108R-1

CD8 (SP16) Rabbit Monoclonal Antibody

• NACRES: NA.41
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: SP16, monoclonal
• Application: IHC (p)
• Citations: 5

Properties

• biological source: rabbit
• Quality Segment: 100, 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: SP16, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (108R-14), vial of 0.5 mL concentrate (108R-15), bottle of 1.0 mL predilute (108R-17), vial of 1.0 mL concentrate (108R-16), bottle of 7.0 mL predilute (108R-18)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
• isotype: IgG1
• control: tonsil
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: membranous
• Gene Information: human ... CD8A(925)

Description

General description

Anti-CD8 is a T-cell marker for the detection of cytotoxic/suppressor lymphocytes. CD8 is also detected on NK cells, most thymocytes, a subpopulation of null cells and bone marrow cells. This antibody, along with other markers, can be used to distinguish between reactive and neoplastic T-cells. Expression of both CD4 (+) and CD8 (+), or lack of expression of both markers in a lymphoid population would be evidence for lymphoma. Although most T-cell lymphoma/leukemias can be either CD8+ or CD8-, CD8 positivity is a factor against Mycosis Fungoides as this entity is negative for CD8. Rarely does anti-CD8 label non-hematolymphoid neoplasms.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

CD8 Positive Control Slides, Product No. 108S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

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Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany