121M-1

CD21 (2G9) Mouse Monoclonal Antibody

• NACRES: NA.41
• UNSPSC Code: 12352203

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: 2G9, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (121M-14); vial of 0.5 mL concentrate (121M-15); bottle of 1.0 mL predilute (121M-17); vial of 1.0 mL concentrate (121M-16); bottle of 7.0 mL predilute (121M-18)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• isotype: IgG2a
• control: tonsil
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: membranous
• Quality Level: 100; 500
• Gene Information: human ... CR2(1380)

Description

General description

CD21 (also known as complement receptor 2 (CR2), C3d receptor, or EBV receptor) is a 140 kDa membrane protein on B-lymphocytes to which the Epstein-Barr virus (EBV) binds during infection of these cells.[1] The antigen is absent on T-lymphocytes, monocytes, and granulocytes.[2][3]
Anti-CD21 is useful in the identification of follicular dendritic cell matrix found in normal lymph nodes and tonsillar tissue. This antibody also labels follicular dendritic cell sarcomas.[2][4][5]

Anti-CD21 is valuable in differentiating follicular lymphoma with marginal zone differentiation from marginal zone lymphoma with follicular involvement. It also plays a role in distinguishing among nodular lymphocyte predominant Hodgkin lymphoma, lymphocyte-rich classic Hodgkin lymphoma, and T-cell/histiocyte-rich B-cell lymphoma in combination with other B-cell and T-cell markers.[6]Anti-CD21 is also useful in identifying abnormal follicular dendritic cell pattern in angioimmunoblastic T-cell lymphoma and follicular T-cell lymphoma.[7]

Other Notes

CD21 Positive Control Slides, Product No. 121S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany