MilliporeSigma
All Photos(1)

16040

Sigma-Aldrich

Pyrogallol

ACS reagent, ≥99%

Synonym(s):
2,3-Dihydroxyphenol, Pyrogallic acid, 1,2,3-Trihydroxybenzene
Linear Formula:
C6H3(OH)3
CAS Number:
Molecular Weight:
126.11
Beilstein:
907431
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

grade

ACS reagent

vapor density

4.4 (vs air)

vapor pressure

10 mmHg ( 167.7 °C)

assay

≥99%

form

solid

technique(s)

HPLC: suitable

ign. residue

≤0.005% (as SO4)

bp

309 °C (lit.)

mp

131.0-135.0 °C
133-134 °C (lit.)

solubility

water: soluble

anion traces

chloride (Cl-): ≤10 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Fe: ≤0.001%
heavy metals (as Pb): ≤0.0005%

application(s)

pharmaceutical (small molecule)

SMILES string

Oc1cccc(O)c1O

InChI

1S/C6H6O3/c7-4-2-1-3-5(8)6(4)9/h1-3,7-9H

InChI key

WQGWDDDVZFFDIG-UHFFFAOYSA-N

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Application

Pyrogallol has been used for preparing endothelial cell extract for determining vitamin E content using reverse-phase HPLC. It has also been used for preparing liver extracts for retinol analysis by using HPLC.

Biochem/physiol Actions

Pyrogallol also referred to as 1,2,3-trihydroxybenzene inhibits the response to nitric oxide (NO) in the rat anococcygeus muscle.

Pictograms

Exclamation markHealth hazard

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Muta. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

J S Gillespie et al.
British journal of pharmacology, 99(1), 194-196 (1990-01-01)
1. The effects of pyrogallol and hydroquinone on the bovine retractor penis (BRP) and rat anococcygeus muscles to non-adrenergic, non-cholinergic (NANC) nerve stimulation have been examined. Both drugs at a concentration of 10(-4) M significantly reduced the response in the
J T Jang et al.
The Journal of nutrition, 130(5), 1291-1296 (2000-05-10)
In view of evidence that nutritional status of iron and vitamin A may affect the other nutrient's metabolism, we used model-based compartmental analysis to examine effects of iron deficiency on whole-body vitamin A dynamics in rats. Weanling male Sprague-Dawley rats
Fufang Wu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 215, 354-362 (2019-03-11)
Theophylline (TP) and theobromine (TB) are the methyl derivatives of xanthine. The antioxidation of TP and TB as well as the effect of the antioxidation and activity of copper‑zinc superoxide dismutase (SOD) with TP and TB were investigated. The contents
A Martin et al.
Arteriosclerosis, thrombosis, and vascular biology, 17(3), 429-436 (1997-03-01)
Monocyte adhesion to human aortic endothelial cells (ECs) is one of the early events in the development of atherogenesis. ECs were used to investigate the role of vitamin E in human monocyte adhesion to ECs in vitro. ECs incubated with
Jeannette Geschwind et al.
Macromolecular rapid communications, 34(2), 150-155 (2012-11-30)
A series of functional polycarbonates, poly((isopropylidene glyceryl glycidyl ether)-co-(glycidyl methyl ether) carbonate) (P((IGG-co-GME) C)) random copolymers with different fractions of 1,2-isopropylidene glyceryl glycidyl ether (IGG) units, is synthesized. After acidic hydrolysis of the acetal protecting groups, a new type of

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