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163M-1

Sigma-Aldrich

CD163 (MRQ-26) Mouse Monoclonal Antibody

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NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-26, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (163M-14)
vial of 0.5 mL concentrate (163M-15)
bottle of 1.0 mL predilute (163M-17)
vial of 1.0 mL concentrate (163M-16)
bottle of 7.0 mL predilute (163M-18)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50

isotype

IgG1

control

inflamed tissue

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, membranous

Gene Information

human ... CD163(9332)

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This Item
MABF3068SAB4701107SAB5500043
conjugate

unconjugated

conjugate

unconjugated

conjugate

Allophycocyanin conjugate

conjugate

unconjugated

antibody form

culture supernatant

antibody form

purified antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

clone

MRQ-26, monoclonal

clone

MAC2-158, monoclonal

clone

GHI/61, monoclonal

clone

SP213, monoclonal

form

buffered aqueous solution

form

-

form

buffered aqueous solution

form

-

species reactivity

human

species reactivity

human

species reactivity

-

species reactivity

human (tested)

General description

CD163, also known as scavenger receptor cysteine-rich type 1 protein M130, is an acute phase-regulated and signal-inducing transmembrane protein found exclusively on cells of monocytic origin. CD163 plays a critical role in macrophage clearance and endocytosis of hemoglobin/haptoglobin complexes. Therefore, CD163 contributes to the anti-inflammatory response and protects tissues from oxidative and inflammatory hemoglobin. Anti-CD163labels cells of monocytic-macrophage lineage, with expression in the bone marrow and histiocytic neoplasms.

Quality


IVD

IVD

IVD

RUO

Linkage

CD163 Positive Control Slides, Product No. 163S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Anders Etzerodt et al.
Antioxidants & redox signaling, 18(17), 2352-2363 (2012-08-21)
The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in inflammation. Accordingly, a high CD163 expression in macrophages
P Högger et al.
Journal of immunology (Baltimore, Md. : 1950), 161(4), 1883-1890 (1998-08-26)
The RM3/1 Ag is a membrane glycoprotein restricted to human monocytes and macrophages that evolve in the late phase of inflammation. Peptide sequence analysis of the RM3/1 protein revealed similarity to CD163, a member of the scavenger receptor cysteine-rich family.
E Backé et al.
Journal of clinical pathology, 44(11), 936-945 (1991-11-01)
A new monoclonal antibody Ber-MAC3 is reported. It recognises a formol sensitive epitope of a not yet clustered monocyte/macrophage specific 140 kilodalton glycoprotein that is expressed on the cell surface and in the cytoplasm. In 30 cases of acute and
Atsushi Hiraoka et al.
Pathology, research and practice, 201(5), 379-384 (2005-07-29)
CD163 is a marker of activated macrophages, and increased levels of soluble CD163 have been detected in sera obtained from patients with hepatitis. The aim of this study was to detect the expression of CD163 in the liver from patients
M Kristiansen et al.
Nature, 409(6817), 198-201 (2001-02-24)
Intravascular haemolysis is a physiological phenomenon as well as a severe pathological complication when accelerated in various autoimmune, infectious (such as malaria) and inherited (such as sickle cell disease) disorders. Haemoglobin released into plasma is captured by the acute phase

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