D-α-Hydroxyglutaric acid disodium salt

≥98.0% (GC)

Disodium (R)-2-hydroxyglutarate, (R)-2-Hydroxypentanedioic acid disodium salt
Linear Formula:
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
MDL number:
PubChem Substance ID:

Quality Level


≥98.0% (GC)

optical activity

[α]/D 8.5±1.5°, c = 1 in NaOH


≤6.0% water

storage temp.


SMILES string




InChI key


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Biochem/physiol Actions

Biomarker for inborn errors of metabolism and cancer


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Andrew J Worth et al.
Chemical research in toxicology, 28(5), 948-954 (2015-03-25)
The α-ketoglutarate metabolite, 2-hydroxyglutarate (2-HG), has emerged as an important mediator in a subset of cancers and rare inherited inborn errors of metabolism. Because of potential enantiospecific metabolism, chiral analysis is essential for determining the biochemical impacts of altered 2-HG...
Stereochemical studies on porphyrin a: assignment of the absolute configuration of a model porphyrin by degradation.
Battersby, A.R., et al.
Journal of the Chemical Society. Perkin Transactions 1, 9, 1565-1580 (1986)
Stereospecific ketonization of 2-hydroxymuconate by 4-oxalocrotonate tautomerase and 5-(carboxymethyl)-2-hydroxymuconate isomerase.
Whitman, C.P., et al.
Journal of the American Chemical Society, 114, 10104-10110 (1992)
Seth J Parker et al.
Pharmacology & therapeutics, 152, 54-62 (2015-05-10)
Specific point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) occur in a variety of cancers, including acute myeloid leukemia (AML), low-grade gliomas, and chondrosarcomas. These mutations inactivate wild-type enzymatic activity and convey neomorphic function to produce d-2-hydroxyglutarate...
K E Yen et al.
Oncogene, 29(49), 6409-6417 (2010-10-26)
The discovery of somatic mutations in the isocitrate dehydrogenase (IDH) enzymes through a genome-wide mutational analysis in glioblastoma represents a milestone event in cancer biology. The nature of the heterozygous, point mutations mapping to arginine residues involved in the substrate...

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