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204M-1

Sigma-Aldrich

ALK Protein (ALK-1) Mouse Monoclonal Antibody

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NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

ALK-1, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (204M-14)
vial of 0.5 mL concentrate (204M-15)
bottle of 1.0 mL predilute (204M-17)
vial of 1.0 mL concentrate (204M-16)
bottle of 7.0 mL predilute (204M-18)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG3κ

control

anaplastic large cell lymphoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, nuclear

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This Item
MABC1171SAB5500105130M-9
conjugate

unconjugated

conjugate

-

conjugate

unconjugated

conjugate

unconjugated

antibody form

culture supernatant

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

culture supernatant

clone

ALK-1, monoclonal

clone

ALK1, monoclonal

clone

SP123, monoclonal

clone

Ber-H2, monoclonal

form

buffered aqueous solution

form

-

form

-

form

buffered aqueous solution

species reactivity

human

species reactivity

human

species reactivity

human (tested)

species reactivity

human

General description

ALK-1 is a novel fusion protein which is detected in 60% of Anaplastic Large Cell Lymphomas and has proven to indicate improved prognosis in the ALK-1 (+) group.

Quality


IVD

IVD

IVD

RUO

Linkage

ALK Protein Positive Control Slides, Product No. 204S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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1000309185

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B Falini et al.
The American journal of pathology, 153(3), 875-886 (1998-09-15)
The t(2;5)(p23;q35) translocation associated with CD30-positive anaplastic large cell lymphoma results in the production of a NPM-ALK chimeric protein, consisting of the N-terminal portion of the NPM protein joined to the entire cytoplasmic domain of the neural receptor tyrosine kinase
K A Cataldo et al.
The American journal of surgical pathology, 23(11), 1386-1392 (1999-11-11)
Anaplastic large cell lymphoma (ALCL) is associated with the t(2;5)(p23;q35) translocation involving the anaplastic lymphoma kinase gene (ALK) and the nucleophosmin gene (NPM), which result in expression of a novel fusion protein, NPM-ALK (p80). Clinicopathologic studies have shown that ALK
S Nakamura et al.
The American journal of surgical pathology, 21(12), 1420-1432 (1997-12-31)
The p80(NPM/ALK) expression activated by the t(2;5) (p23;q35) translocation recently has been shown to play an important role in the pathogenesis of anaplastic large cell lymphoma (ALCL). However, the clinicopathologic significance of identification of p80 among ALCL cases has not

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