Documents
22620
Quinine
suitable for fluorescence, anhydrous, ≥98.0% (dried material, NT)
Recommended Products
Quality Level
Assay
≥98.0% (dried material, NT)
form
powder
optical activity
[α]20/D −126±5°, c = 1% in chloroform
impurities
≤5% dihydroquinine (HPLC)
loss
≤1% loss on drying, 110 °C
mp
173-175 °C (lit.)
solubility
H2O: soluble
fluorescence
λex 347 nm; λem 448 nm in 0.5 M sulfuric acid
suitability
suitable for fluorescence
SMILES string
COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1
InChI
1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1
InChI key
LOUPRKONTZGTKE-WZBLMQSHSA-N
Gene Information
human ... ABCB1(5243) , CYP2C9(1559) , CYP2D6(1565)
rat ... Cyp2d1(266684) , Cyp2d2(25053) , Cyp2d3(24303) , Cyp2d4v1(171522)
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1 of 4
This Item | PHL80962 | 22600 | 145904 |
|---|---|---|---|
| form powder | form - | form solid | form - |
| optical activity [α]20/D −126±5°, c = 1% in chloroform | optical activity - | optical activity [α]20/D +265±5°, c = 0.8% in ethanol (dry matter) | optical activity [α]25/D −165°, c = 2 in ethanol |
| mp 173-175 °C (lit.) | mp 173-175 °C (lit.) | mp 168-172 °C (lit.) | mp 173-175 °C (lit.) |
| impurities ≤5% dihydroquinine (HPLC) | impurities - | impurities ≤2% water, ~10% hydroquinidine (HPLC) | impurities - |
| loss ≤1% loss on drying, 110 °C | loss - | loss - | loss - |
General description
Application
- To study its in vitro antimalarial activity in combination with omeprazole.
- To analyze its effect on viscosity and friction of saliva.
- As a test agent to study its impact on the accumulation of the fluorescent P-glycoprotein (Pgp) substrates in P-glycoprotein overexpressing breast cancer cells.
- To study its influence on the pyramidal cell intrinsic properties, extracellular potassium transients, and epileptiform activity in vitro.
- As a reference compound to identify alkaloids by phytochemical screening of Deianira erubescens, Strychnos pseudoquina and Remijia ferruginea plants.
Biochem/physiol Actions
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Personal Protective Equipment
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