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23120

Sigma-Aldrich

α-Chloralose

≥98.0% (chloralose, AT)

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Synonym(s):
1,2-O-(2,2,2-Trichloroethylidene)-α-D-glucofuranose, Anhydro-D-glucochloral, Chloralose
Empirical Formula (Hill Notation):
C8H11Cl3O6
CAS Number:
Molecular Weight:
309.53
Beilstein:
85418
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

Assay

≥98.0% (chloralose, AT)

form

powder

optical activity

[α]20/D +17±2°, 5 hr, c = 2% in ethanol

impurities

15% Beta-chloralose

mp

178-184 °C

solubility

water: soluble 1 gm in 225 ml at 15 °C
chloroform: slightly soluble
diethyl ether: soluble
glacial acetic acid: soluble
petroleum ether: insoluble

SMILES string

OC[C@@H](O)[C@H]1O[C@@H]2O[C@@H](O[C@@H]2[C@H]1O)C(Cl)(Cl)Cl

InChI

1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1

InChI key

OJYGBLRPYBAHRT-IPQSZEQASA-N

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636206341863630
α-Chloralose ≥98.0% (chloralose, AT)

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23120

α-Chloralose

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D-(+)-Maltose monohydrate BioUltra, ≥99.0% (HPLC)

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D-(+)-Maltose monohydrate

Premium Grade
D-(+)-Melibiose suitable for microbiology, ≥99.0%

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63630

D-(+)-Melibiose

-
form

powder

form

powder

form

powder or crystals

form

powder

impurities

15% Beta-chloralose

impurities

-

impurities

insoluble matter, passes filter test

impurities

-

mp

178-184 °C

mp

154-160 °C (dec.)

mp

125 -130  °C

mp

-

solubility

water: soluble 1 gm in 225 ml at 15 °C, chloroform: slightly soluble, diethyl ether: soluble, glacial acetic acid: soluble, petroleum ether: insoluble

solubility

H2O: 50 mg/mL, clear, colorless

solubility

H2O: 0.5 M at 20 °C, clear, colorless

solubility

H2O: 0.1 g/mL, clear, colorless

optical activity

[α]20/D +17±2°, 5 hr, c = 2% in ethanol

optical activity

[α]20/D +88±2°, c = 4% in H2O

optical activity

[α]20/D +130±2°, 24 hr, c = 4% in H2O

optical activity

[α]20/D +137±3°, 10 hr, c = 5% in H2O

Biochem/physiol Actions

α-Chloralose stimulates the gama-aminobutyric acid (GABA)-induced chloride conductance of gama-aminobutyric acidA (GABAA) receptors expressed in Xenopus laevis oocytes.

Components

mixture of isomers of ~85% α-chloralose; ~15% β-chloralose

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Pictograms

Skull and crossbonesEnvironment

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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K M Garrett et al.
The Journal of pharmacology and experimental therapeutics, 285(2), 680-686 (1998-05-15)
alpha-Chloralose is widely used as an anesthetic in the laboratory due to its minimal effects on autonomic and cardiovascular systems, yet little is known about its mechanism of action. We examined the effects of alpha-chloralose on gamma-aminobutyric acid type A
R W Gear et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(16), 7175-7181 (1999-08-06)
We tested the hypothesis that noxious stimuli induce pain modulation by activation of supraspinal structures. We found that intense noxious stimuli (i.e., subdermal injection of capsaicin or paw immersion in hot water) induced profound attenuation of the jaw-opening reflex in
Renata F Leoni et al.
NeuroImage, 58(1), 75-81 (2011-06-29)
Hypertension afflicts 25% of the general population and over 50% of the elderly. In the present work, arterial spin labeling MRI was used to non-invasively quantify regional cerebral blood flow (CBF), cerebrovascular resistance and CO(2) reactivity in spontaneously hypertensive rats
Hongxia Lei et al.
Journal of neuroscience research, 88(2), 413-419 (2009-09-12)
Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the case of (1)H
Mingming Zhu et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 179(6), 701-710 (2009-03-12)
Direct measurements of deep-brain and body-core temperature were performed on rats to determine the influence of cerebral blood flow (CBF) on brain temperature regulation under static and dynamic conditions. Static changes of CBF were achieved using different anesthetics (chloral hydrate

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