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277M-9

Sigma-Aldrich

Lambda (Lamb14) Mouse Monoclonal Antibody

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biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

Lamb14, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (277M-94)
vial of 0.5 mL concentrate (277M-95)
bottle of 1.0 mL predilute (277M-97)
vial of 1.0 mL concentrate (277M-96)
bottle of 7.0 mL predilute (277M-98)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG2a

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

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This Item
277R-1274R-1SAB5500122
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

affinity isolated antibody

clone

Lamb14, monoclonal

clone

EP172, monoclonal

clone

EP171, monoclonal

clone

SP148, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

-

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human (tested)

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General description

Anti-lambda detects surface immunoglobulin on normal and neoplastic B-cells. Anti-lambda staining is seen in B-cell follicles of human lymphoid tissue. When dealing with B-cell neoplasms, the determination of light chain ratios remains helpful. Most B-cell lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda positive cells. If only a single light chain type is detected, a lymphoproliferative disorder is very likely. Monoclonality is determined by a kappa-lambda ratio of greater than 3:1, a lambda-kappa ratio greater than 2:1.

Quality


IVD

IVD

IVD

RUO

Linkage

Lambda Positive Control Slides, Product No. 277S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Certificates of Analysis (COA)

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M Ashton-Key et al.
Histopathology, 29(6), 525-531 (1996-12-01)
We have compared light chain immunohistochemistry in reactive lymphoid tissue and a series of paraffin-embedded B-cell lymphomas using standard trypsin digestion with a heat mediated epitope retrieval method. Fifty-seven B-cell lymphomas (18 high grade, 29 low grade and 10 cases
S L Abbondanzo
Annals of diagnostic pathology, 3(5), 318-327 (1999-11-11)
In the past two decades, there have been a number of dramatic advances in immunology that have subsequently affected immunohistochemistry. These have had a substantial impact on all phases of laboratory medicine, especially surgical pathology. Many hospital laboratories use immunohistochemical
P J Kurtin et al.
American journal of clinical pathology, 112(3), 319-329 (1999-09-09)
The immunoperoxidase technique was used with antibodies against B-cell-associated antigens, including CD20, CD79a, CD10, CD23, CD43, cyclin D1, bcl-2, and kappa and lambda immunoglobulin light chains on formalin-fixed and B5-fixed tissue sections of follicular, small lymphocytic, mantle cell, and marginal

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