This product is not tested for solubility. Other Corticosterone products available, such as C2505 and 235135, indicate that this material is soluble in Ethanol at 50 mg/mL. A brief search of this literature indicates that the compound is also soluble in DMSO at 69 mg/mL ( (199.15 mM).
27840
Corticosterone
≥98.5% (HPLC)
Synonym(s):
11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 mg | Available to ship TODAYfromMILWAUKEE | $36.70 | |
| 500 mg | Available to ship TODAYfromMILWAUKEE | $139.00 |
About This Item
Empirical Formula (Hill Notation):
C21H30O4
CAS Number:
Molecular Weight:
346.46
UNSPSC Code:
12352211
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-019-6
Beilstein/REAXYS Number:
2339601
MDL number:
$36.70
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biological source
synthetic
Quality Level
assay
≥98.5% (HPLC)
form
powder or crystals
optical activity
[α]20/D +223±3°, c = 1% in ethanol
mp
179-183 °C
functional group
ketone
SMILES string
C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
InChI
1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChI key
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
Gene Information
human ... EBP(10682), SERPINA6(866)
rat ... Ar(24208), Nr3c1(24413)
General description
Application
Biochem/physiol Actions
Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. The role of corticosterones is vital for reproductive processes including ovulation, lutenization, development of oocytes, parturition and lactation. The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase.[8][9]
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Preparation Note
Corticosterone is soluble in chloroform and ethanol.
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98.5% (HPLC) | assay ≥92% | assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| functional group ketone | functional group - | functional group - | functional group - |
| biological source synthetic | biological source synthetic (organic) | biological source - | biological source - |
| form powder or crystals | form powder | form - | form crystalline powder |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| mp 179-183 °C | mp 179-183 °C (lit.) | mp 179-183 °C (lit.) | mp - |
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A M Iacopino et al.
The Journal of biological chemistry, 265(18), 10177-10180 (1990-06-25)
Corticosterone was administered to normal and bilaterally adrenalectomized rats (250-300 g), and hormonal regulation of brain calbindin-D28k (CaBP28k) levels was investigated by radioimmunoassay for CaBP28k protein and by slot and Northern blot analyses for CaBP28k mRNA. The specificity of the
D F DeNardo et al.
Hormones and behavior, 27(2), 184-199 (1993-06-01)
Adrenal corticoid release is a major component of the stress response which can affect many body functions including behavior. The purpose of our studies was to examine the effects of corticosterone (B) on both the agonistic and courtship components of
Amanda J Rickard et al.
Journal of molecular endocrinology, 42(6), 449-459 (2009-01-23)
The mineralocorticoid receptor (MR) and glucocorticoid receptor are ligand-activated transcription factors that have important physiological and pathophysiological actions in a broad range of cell types including monocytes and macrophages. While the glucocorticoids cortisol and corticosterone have well-described anti-inflammatory actions on
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 27840-100MG | 04061826203439 |
| 27840-500MG | 04061826203446 |
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what is the solubility of Corticosterone in DMSO or ethanol?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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