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282200

Sigma-Aldrich

Galangin

autophagy inducing flavonoid

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Synonym(s):
3,5,7-Trihydroxyflavone, Norizalpinin
Empirical Formula (Hill Notation):
C15H10O5
CAS Number:
Molecular Weight:
270.24
Beilstein/REAXYS Number:
272179
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.79

Quality Level

assay

≥95% (HPLC)

form

powder

color

yellow

mp

214-215 °C (lit.)

SMILES string

Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3

InChI

1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H

InChI key

VCCRNZQBSJXYJD-UHFFFAOYSA-N

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This Item
G0278G829392342
Galangin autophagy inducing flavonoid

282200

Galangin

Galanin human ≥97% (HPLC), powder

G0278

Galanin human

Galanin (2-11) porcine, rat ≥97% (HPLC), lyophilized powder

G8293

Galanin (2-11) porcine, rat

Galangin analytical standard

92342

Galangin

form

powder

form

powder

form

lyophilized powder

form

powder or crystals

mp

214-215 °C (lit.)

mp

-

mp

-

mp

214-215 °C (lit.)

color

yellow

color

-

color

-

color

faint yellow to dark yellow

Gene Information

human ... ADORA2A(135), ADORA3(140), CYP1A2(1544)
rat ... Adora1(29290), Adora2a(25369)

Gene Information

human ... GAL(51083)

Gene Information

rat ... Gal(29141)

Gene Information

-

General description

Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.

Application

Galangin has been used:
  • as a test drug to test its ameliorative effect in a rodent model of cisplatin-induced nephrotoxicity
  • to test its effect on the differentiation of 3T3-L1 preadipocyte cells into adipocytes
  • as an internal standard in nuclear magnetic resonance spectroscopy and mass spectroscopy

Biochem/physiol Actions

Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory and anti-obesity properties. In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis. Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Articles

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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