2854

Sigma-Aldrich

Ethylenediaminetetraacetic acid disodium salt solution

2%, solution

Synonym(s):
EDTA disodium salt, (Ethylenedinitrilo)tetraacetic acid disodium salt, EDTA-Na2
Linear Formula:
[-CH2N(CH2CO2Na)CH2CO2H]2
CAS Number:
Molecular Weight:
336.21
Beilstein/REAXYS Number:
3822669
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

form

solution

concentration

2%

storage temp.

2-8°C

SMILES string

[Na+].[Na+].OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;/q;2*+1/p-2

InChI key

ZGTMUACCHSMWAC-UHFFFAOYSA-L

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General description

Ethylenediamine tetraacetate (EDTA) is a calcium ion chelator, that has a low molecular mass of 292.24 Da.

Biochem/physiol Actions

Ethylenediaminetetraacetic acid disodium salt has the ability to block the binding of vasoactive intestinal peptide to macrophage membranes. It is mainly used in the purification of protein, to remove divalent cations and also to prevent protease activity.

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

J J Segura et al.
Journal of endodontics, 22(7), 337-340 (1996-07-01)
The purpose of this study was to investigate the effect of the disodium salt of ethylenediamine tetraacetate (EDTA), a calcium ion chelator used in the root canal therapy, on vasoactive intestinal peptide (VIP) binding to macrophage membranes (MM's). Binding assays...
Drawbacks of dialysis procedures for removal of EDTA
Monico A, et al.
PLoS ONE, 12(1), e0169843-e0169843 (2017)
Sabrina Lusvarghi et al.
Nucleic acids research, 41(13), 6637-6649 (2013-05-04)
Interaction between the viral protein Rev and the RNA motifs known as Rev response elements (RREs) is required for transport of unspliced and partially spliced human immunodeficiency virus (HIV)-1 and HIV-2 RNAs from the nucleus to the cytoplasm during the...
Romain Coriat et al.
The Journal of clinical investigation, 124(1), 262-272 (2013-12-21)
The majority of patients receiving the platinum-based chemotherapy drug oxaliplatin develop peripheral neurotoxicity. Because this neurotoxicity involves ROS production, we investigated the efficacy of mangafodipir, a molecule that has antioxidant properties and is approved for use as an MRI contrast...
Oivind Midttun et al.
The Journal of nutrition, 144(5), 784-790 (2014-03-22)
Knowledge of stability during sample transportation and changes in biomarker concentrations within person over time are paramount for proper design and interpretation of epidemiologic studies based on a single measurement of biomarker status. Therefore, we investigated stability and intraindividual vs....

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