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30432

Dansylcadaverine

BioReagent, suitable for fluorescence, ≥99.0% (HPLC)

Synonym(s):

N-(5-Amino­pentyl)-5-di­methyl­amino­naphtha­lene-1-sulfon­amide, N-(Dimethyl­amino­naphtha­lene­sulfonyl)-1,5-pentane­diamine, Monodansyl cadaverine

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100 mg

Available to ship TODAYfromMILWAUKEE

$55.90
1 g

Available to ship TODAYfromMILWAUKEE

$281.00

About This Item

Empirical Formula (Hill Notation):
C17H25N3O2S
CAS Number:
10121-91-2
Molecular Weight:
335.46
UNSPSC Code:
12352108
NACRES:
NA.32
PubChem Substance ID:
57648439
EC Number:
233-326-9
Beilstein/REAXYS Number:
2951070
MDL number:
MFCD00042704

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product line

BioReagent

Quality Level

100

assay

≥99.0% (HPLC)

mp

137-140 °C

fluorescence

λex 335 nm; λem 518 nm in methanol, λex 338 nm; λem 500 nm (Reaction product)

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN

InChI

1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3

InChI key

MLEBFEHOJICQQS-UHFFFAOYSA-N

Application

Dansylcadaverine (MDC), an autofluorescent dye, is used to monitor autophagy. MDC accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

Biochem/physiol Actions

Inhibitor of the fibrin-stabilizing fator;[1] Inhibitor of epidermal growth factor (EGF) internalization;[2] Fluorescent substrate for the assay of transamidating enzymes.[3][4]
The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.
air sensitive, handled under inert gas

Other Notes

Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid.

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This Item
D4008D2260633211
Dansylcadaverine BioReagent, suitable for fluorescence, ≥99.0% (HPLC)

Sigma-Aldrich

30432

Dansylcadaverine

Dansylcadaverine ≥97% (TLC)

Sigma-Aldrich

D4008

Dansylcadaverine

Cadaverine 95%

Sigma-Aldrich

D22606

Cadaverine

Cadaverine purum, ≥97.0% (GC)

Sigma-Aldrich

33211

Cadaverine

suitability

suitable for fluorescence

suitability

-

suitability

-

suitability

-

fluorescence

λex 335 nm; λem 518 nm in methanol, λex 338 nm; λem 500 nm (Reaction product)

fluorescence

-

fluorescence

-

fluorescence

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

-

assay

≥99.0% (HPLC)

assay

≥97% (TLC)

assay

95%

assay

≥97.0% (GC)

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

product line

BioReagent

product line

-

product line

-

product line

-

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ9453
BCCD4415
BCBX0277
BCBQ5694V
BCBM3760V

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Qi Jiang et al.
The Journal of urology, 188(4), 1361-1368 (2012-08-22)
Androgen receptor has a critical role in prostate cancer development and progression. Cell death via autophagy may also contribute to prostate cancer progression. We determined the role and regulatory effects of androgen receptor on the autophagy process of prostate cancer
H T Haigler et al.
The Journal of biological chemistry, 255(4), 1239-1241 (1980-02-25)
The binding and internalization of 125I-epidermal growth factor (125I-EGF) was studied in cultures of BALB 3T3 cells using a novel method that involved removal of cell-surface hormone by treatment with acetic acid under conditions that did not remove internalized hormone.
Transamidating enzymes. I. Rapid chromatographic assays.
L Lorand et al.
Analytical biochemistry, 44(1), 207-220 (1971-11-01)
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Global Trade Item Number

SKUGTIN
30432-100MG04061826666838
30432-1G04061826666845

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