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324R-1

Sigma-Aldrich

PSA (EP109) Rabbit Monoclonal Primary Antibody

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Synonym(s):
APS, KLK2A1, P-30 antigen, gamma-seminoprotein, hK3, kallikrein-3, kallikrein-related peptidase 3, prostate specific antigen, semenogelase, seminin

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

Ig fraction of antiserum

antibody product type

primary antibodies

clone

EP109, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (324R-14)
vial of 0.5 mL concentrate (324R-15)
vial of 1.0 mL concentrate (324R-16)
vial of 1.0 mL pre-dilute ready-to-use (324R-17)
vial of 7.0 mL pre-dilute ready-to-use (324R-18)

manufacturer/tradename

Cell Marque

concentration

0.1-0.5 μg/mL (predilute)
10-500 μg/mL (concentrate)

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

isotype

IgG

control

prostate carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... KLK3(354)

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This Item
327R-1324M-1326M-1
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

Ig fraction of antiserum

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

clone

EP109, monoclonal

clone

EP192, monoclonal

clone

ER-PR8, monoclonal

clone

PASE/4LJ, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

General description

Prostate-Specific Antigen (PSA) is a 33 kDa protein primarily produced by the prostatic epithelium and the epithelial lining of the periurethral glands. PSA is strongly expressed in both normal and neoplastic prostatic tissue. Anti-PSA is most useful in determining the prostatic origin of carcinomas in non-prostate tissues (metastatic disease) using IHC techniques.,,,

Quality

Canada - IVD
European Union - IVD
Japan - RUO
United States - IVD

Caution

Do not freeze

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Diagnostic utility of immunohistochemistry in morphologically difficult prostate cancer: review of current literature.
Varma, M., and Jasani, B.
Histopathology, 47, 1-16 (2005)
Prostate specific antigen: a decade of discovery -- what we have learned and where we are going.
Polascik, T.J., et al.
The Journal of Urology, 162, 293-306 (1999)
Prostate-specific antigen.
Stenman, U.H., et al.
Seminars in Cancer Biology, 9, 83-93 (1999)
K A Alanen et al.
Pathology, research and practice, 192(3), 233-237 (1996-03-01)
Immunohistochemical detection of prostate specific antigen (PSA) in metastases of adenocarcinomas is widely used as an aid to identify the prostatic origin of metastatic cells. However, on the one hand, PSA may not be expressed in some poorly differentiated prostatic
M Varma et al.
Histopathology, 47(1), 1-16 (2005-06-29)
Varma M & Jasani B (2005) Histopathology47, 1-16 Diagnostic utility of immunohistochemistry in morphologically difficult prostate cancer: review of current literatureImmunohistochemistry is widely used to distinguish prostate cancer from benign mimics and to establish the prostatic origin of poorly differentiated

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