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332R-1

Sigma-Aldrich

Somatostatin (EP130) Rabbit Monoclonal Primary Antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP130, monoclonal

description

(For In Vitro Diagnostic Use in Select Regions (See Chart))

form

buffered aqueous solution

species reactivity

human

packaging

bottle of 1.0 mL predilute (332R-17)
bottle of 7.0 mL predilute (332R-18)
vial of 0.1 mL concentrate (332R-14)
vial of 0.5 mL concentrate (332R-15)
vial of 1.0 mL concentrate (332R-16)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... SST(6750)

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species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

clone

EP130, monoclonal

clone

EP149

clone

EP193, monoclonal

clone

EP254, monoclonal

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

culture supernatant

antibody form

IgG fraction of antiserum

antibody form

culture supernatant

antibody form

culture supernatant

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

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General description

Somatostatin is a peptide hormone widely distributed throughout the body and is an important regulator of endocrine and nervous system function. Somatostatin can also be found in gastrointestinal and bronchopulmonary endocrine cells, thymic endocrine cells, and thyroid C-cells. Anti-somatostatin is a useful marker of D-cells of pancreatic islet cells.1,2 D-cells identification can be used to identify hyperplasia of the pancreatic islets of Langerhans and tumors arising from these cells. Anti-somatostatin recognizes somatostatin-containing cells in pancreatic tumors, islet cell hyperplasia, and islet cells originating in pancreatic ductules.3-7

Quality


IVD

IVD

IVD

RUO

Linkage

Somatostatin Positive Control Slides, Product No. 332S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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G Chejfec et al.
Ultrastructural pathology, 16(5), 537-545 (1992-09-01)
Upper gastrointestinal tract neuroendocrine tumors producing predominantly somatostatin have thus far been described only in the duodenum; their characteristic features include the frequent presence of psammoma bodies (psammomatous somatostinomas), and the association with von Recklinghausen's neurofibromatosis. Gastric neuroendocrine tumors, on
G J Krejs et al.
The New England journal of medicine, 301(6), 285-292 (1979-08-09)
Diabetes mellitus, steatorrhea, cholelithiasis and a tumor distorting the duodenum prompted a work-up for somatostatinoma in a 52-year-old man. The responses of pancreatic B-cells but not of A-cells to nutrient stimuli were inhibited, and growth-hormone release was suppressed, suggesting somatostatin
Maria Angelova Tzaneva
Acta histochemica, 105(2), 191-201 (2003-07-02)
Five types of endocrine cells are found in the human antral gastric mucosa: gastrin (G) cells, somatostatin (D) cells, enterochromaffin (EC) cells and cells with an unknown secretory product (D1 cells and P cells). The content of secretory granules, gastrin
P Kanavaros et al.
Histology and histopathology, 5(3), 325-328 (1990-07-01)
Serotonin-producing pancreatic endocrine tumours are rare neoplasms which in most cases exhibit malignant biological behaviour. These tumours, in the majority of the well-documented cases, are composed of argyrophil- and argentaffin-positive cells which contain large pleomorphic neurosecretory granules. In contrast, argyrophilic

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