340M-9

Sigma-Aldrich

Thyroglobulin (MRQ-41) Mouse Monoclonal Antibody

Pricing and availability is not currently available.

Quality Level

biological source

mouse

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-41, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (340M-94)
vial of 0.5 mL concentrate (340M-95)
bottle of 1.0 mL predilute (340M-97)
vial of 1.0 mL concentrate (340M-96)
bottle of 7.0 mL predilute (340M-98)

mfr. no.

Cell Marque

application(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1

conjugate

unconjugated

control

thyroid

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

General description

Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Anti-Thyroglobulin, combined with TTF1 are demonstrable by immunohistochemistry assay in the majority of thyroid neoplasms. A panel of antibodies for Thyroglobulin, TTF1, CK-7, CK19, and CK20 is useful when thyroid is the possible primary site of a metastatic tumor.

Quality


IVD

IVD

IVD

RUO

Linkage

Thyroglobulin Positive Control Slides, Product No. 340S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Clara S Heffess et al.
Cancer, 95(9), 1869-1878 (2002-10-31)
Clear cell tumors of the thyroid gland in general are uncommon. Metastatic renal cell carcinoma (RCC) to the thyroid gland is a rare occurrence but must be considered in the differential diagnosis of a thyroid gland clear cell neoplasm to...
D Bellet et al.
The Journal of clinical endocrinology and metabolism, 56(3), 530-533 (1983-03-01)
Human thyroglobulin (Tg) was used as an antigen in the development of antibodies by the hybridoma technique. From four antibodies that bound more than 40% labeled Tg, two were characterized (182/E4 and 211/A5). They were both of the immunoglobulin G...
P A Bejarano et al.
Applied immunohistochemistry & molecular morphology : AIMM, 8(3), 189-194 (2000-09-12)
Thyroid transcription factor-1 (TTF-1), a member of the NKx2 family of homeodomain transcription factors, is a mediator of thyroid-specific transcription of the thyroglobulin (TG) gene. The combined immunohistochemical profile of TTF-1, TG, cytokeratin 7 (CK7), and cytokeratin 20 (CK20) in...

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