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Uroplakin III (SP73) Rabbit Monoclonal Antibody

Name: Uroplakin III (SP73) Rabbit Monoclonal Antibody
Brand: SIGMA

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

SP73, monoclonal

Application:

IHC (p)

Citations:

This product is discontinued. Contact Technical Servicefor assistance.

Properties

biological source

rabbit

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

SP73, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (345R-14), vial of 0.5 mL concentrate (345R-15), bottle of 1.0 mL predilute (345R-17), vial of 1.0 mL concentrate (345R-16), bottle of 7.0 mL predilute (345R-18)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500-1:1000

isotype

IgG

control

bladder

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

Gene Information

human ... UPK3A(7380)

Description

General description

Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II, and III) that are specific differentiation products of urothelial cells. In non-neoplastic mammalian urothelium, UPs are expressed in the luminal surface plasmalemma of superficial (umbrella) cells, forming complexes of 16nm crystalline particles. UPIII is specific for tumors of urothelial origin and, when used in combination with other markers, can aid in the diagnosis of primary and metastatic tumors.[1]

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Uroplakin III Positive Control Slides, Product No. 345S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Show Differences

1 of 1

This Item	345M-1	SAB5500189	HPA010506
Sigma-Aldrich 345R-1 Uroplakin III (SP73) Rabbit Monoclonal Antibody	Sigma-Aldrich 345M-1 Uroplakin III (AU-1) Mouse Monoclonal Antibody	Sigma-Aldrich SAB5500189 Anti-Uroplakin III antibody, Rabbit monoclonal	Sigma-Aldrich HPA010506 Anti-UPK3B antibody produced in rabbit
species reactivity human	species reactivity human	species reactivity human (tested)	species reactivity human
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
clone SP73, monoclonal	clone AU-1, monoclonal	clone SP73, monoclonal	clone polyclonal
antibody form culture supernatant	antibody form culture supernatant	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Loss of uroplakin III expression is associated with a poor prognosis in patients with urothelial carcinoma of the upper urinary tract.

Yukihiro Ohtsuka et al.

BJU international, 97(6), 1322-1326 (2006-05-12)

To investigate the association between the expression of uroplakin III (UPIII) and the prognosis of patients with urothelial carcinoma of the upper urinary tract, as uroplakins are urothelium-specific markers of terminal urothelial differentiation. Clinicopathological and follow-up data from 71 patients

Uroplakin gene expression in normal human tissues and locally advanced bladder cancer.

Jonathon Olsburgh et al.

The Journal of pathology, 199(1), 41-49 (2002-12-11)

The uroplakins are widely regarded as urothelium-specific markers of terminal urothelial cytodifferentiation. This study investigated the expression of the four uroplakin genes, UPIa, UPIb, UPII and UPIII, in a wide range of normal human tissues to determine tissue specificity and

Uroplakins, specific membrane proteins of urothelial umbrella cells, as histological markers of metastatic transitional cell carcinomas.

R Moll et al.

The American journal of pathology, 147(5), 1383-1397 (1995-11-01)

Uroplakins (UPs) Ia, Ib, II, and III, transmembrane proteins constituting the asymmetrical unit membrane of urothelial umbrella cells, are the first specific urothelial differentiation markers described. We investigated the presence and localization patterns of UPs in various human carcinomas by

Global Trade Item Number

SKU	GTIN
345R-17	0841683137559
345R-14	0841683137528
345R-15	0841683137535
345R-16	0841683137542
345R-18	0841683137566

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