The target information for UniProt accession P23771 indicates that it is a transcriptional activator that binds to the enhancer of the T-cell receptor alpha and delta genes. It specifically binds to the consensus sequence 5'-AGATAG-3'.
390M-1
GATA3 (L50-823) Mouse Monoclonal Antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
L50-823, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (390M-14)
vial of 0.5 mL concentrate (390M-15)
bottle of 1.0 mL predilute (390M-17)
vial of 1.0 mL concentrate (390M-16)
bottle of 7.0 mL predilute (390M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype
IgG1κ
control
breast carcinoma, urothelial carcinoma
shipped in
wet ice
storage temp.
2-8°C
visualization
nuclear
Gene Information
human ... GATA3(2625)
Related Categories
1 of 4
This Item | MABD117 | AV32548 | 405M-1 |
|---|---|---|---|
| clone L50-823, monoclonal | clone 7B5, monoclonal | clone polyclonal | clone 2F83, monoclonal |
| species reactivity human | species reactivity human | species reactivity human | species reactivity human |
| conjugate unconjugated | conjugate - | conjugate unconjugated | conjugate unconjugated |
| biological source mouse | biological source mouse | biological source rabbit | biological source mouse |
| antibody form culture supernatant | antibody form ascites fluid | antibody form affinity isolated antibody | antibody form culture supernatant |
| form buffered aqueous solution | form - | form buffered aqueous solution | form buffered aqueous solution |
General description
GATA binding protein 3 or GATA3, is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types. The human GATA3 gene has been mapped to chromosome10p15. GATA3 expression is primarily seen in breast carcinoma and urothelial carcinoma. [1] [2] Anti-GATA3 can also be useful in the identification of unknown primary carcinoma when carcinomas of the breast or bladder are a possibility
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
For Technical Service please contact: 800-665-7284 or email: [email protected]
GATA3 Positive Control Slides, Product No. 390S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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V Joulin et al.
The EMBO journal, 10(7), 1809-1816 (1991-07-01)
The human GATA1, hGATA1 (previously called NF-E1, GF-1 or Eryf-1), a major sequence-specific DNA-binding protein of the erythrocytic lineage, is a member of a zinc-finger family of DNA-binding proteins. We report here the cloning of a human cDNA for a
M C Labastie et al.
Genomics, 21(1), 1-6 (1994-05-01)
GATA3, a member of the GATA family that is abundantly expressed in the T-lymphocyte lineage, is thought to participate in T-cell receptor gene activation through binding to enhancers. To understand GATA3 gene regulation, we cloned the human gene and the
Haiyan Liu et al.
American journal of clinical pathology, 138(1), 57-64 (2012-06-19)
GATA3 expression has been reported in urothelial and breast carcinomas; however, the published data on GATA3 expression in tumors from other organs are limited. Immunohistochemical evaluation of GATA3 expression in 1,110 carcinomas and 310 cases of normal tissue using tissue
Huadong Lai et al.
International journal of cancer, 149(12), 2099-2115 (2021-09-05)
Bladder cancer represents a highly heterogeneous disease characterized by distinct histological, molecular and clinical phenotypes, and a detailed analysis of tumor cell invasion and crosstalks within bladder tumor cells has not been determined. Here, we applied droplet-based single-cell RNA sequencing
John P T Higgins et al.
The American journal of surgical pathology, 31(5), 673-680 (2007-04-27)
The morphologic distinction between prostate and urothelial carcinoma can be difficult. To identify novel diagnostic markers that may aid in the differential diagnosis of prostate versus urothelial carcinoma, we analyzed expression patterns in prostate and bladder cancer tissues using complementary
Related Content
Diagnostic immunohistochemistry overview highlights its importance in cancer diagnosis and detecting infectious diseases in modern clinical pathology.
Una visión general de la inmunohistoquímica diagnóstica destaca su importancia en el diagnóstico del cáncer y la detección de enfermedades infecciosas en la anatomopatología moderna.
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