41698

Sigma-Aldrich

Atto 488 NHS ester

BioReagent, suitable for fluorescence, ≥80% (coupling to amines)

NACRES:
NA.32

Quality Level

product line

BioReagent

assay

≥80% (coupling to amines)

fluorescence

λex 498 nm; λem 520 nm in 0.1 M phosphate pH 7.0

suitability

suitable for fluorescence

storage temp.

−20°C

Application

Atto fluorescent labels are designed for high sensitivity applications, including single molecule detection. Atto labels have rigid structures that do not show any cis-trans-isomerization. Thus these labels display exceptional intensity with minimal spectral shift on conjugation. Atto 488 NHS ester is used to label molecules via conjugation to primary amine groups.

Legal Information

This product is for Research use only. In case of intended commercialization, please contact the IP-holder (ATTO-TEC GmbH, Germany) for licensing.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Analysis of fluorescent nanostructures in biological systems by means of spectral position determination microscopy (SPDM).
Muller, P., et al. et al.
Current Microscopy Contributions to Advances in Science and Technology, 1, 3-12 (2012)
Karuppiah Chockalingam et al.
Scientific reports, 10(1), 2888-2888 (2020-02-23)
Fabs offer an attractive platform for monoclonal antibody discovery/engineering, but library construction can be cumbersome. We report a simple method - Golden Gate assembly with a bi-directional promoter (GBid) - for constructing phage display Fab libraries. In GBid, the constant...
Qian Peter Su et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(26), 15036-15046 (2020-06-17)
Mammalian DNA replication is initiated at numerous replication origins, which are clustered into thousands of replication domains (RDs) across the genome. However, it remains unclear whether the replication origins within each RD are activated stochastically or preferentially near certain chromatin...
Kin Man Suen et al.
Nature communications, 11(1), 4242-4242 (2020-08-28)
Membraneless organelles are sites for RNA biology including small non-coding RNA (ncRNA) mediated gene silencing. How small ncRNAs utilise phase separated environments for their function is unclear. We investigated how the PIWI-interacting RNA (piRNA) pathway engages with the membraneless organelle...
Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid.
Iserman, et al.
Molecular Cell, 80, 1078-1091 (2021)
Articles
Fluorescent Labeling of Peptides
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