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424M-1

Sigma-Aldrich

CITED1 (5H6) Mouse Monoclonal Antibody

NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

5H6, monoclonal

description

(For In Vitro Diagnostic Use in Select Regions (See Chart))

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (424M-14)
vial of 0.5 mL concentrate (424M-15)
bottle of 1.0 mL predilute (424M-17)
vial of 1.0 mL concentrate (424M-16)
bottle of 7.0 mL predilute (424M-18)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG2aκ

control

Wilms’ tumor

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... CITED1(4435)

General description

CITED1 is a transcriptional cofactor expressed in the metanephric mesenchyme (MM) of the embryonic kidney and is down-regulated as these cells undergo epithelial differentiation.1-4 It is thought that CITED1 may play a role in maintaining MM cells in an undifferentiated state.3 Wilms′ tumors (WT) are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed MM within embryonic kidneys.1 CITED1 expression has been shown to persist in blastemal cell populations of human WT.1,2 In the developing embryonic kidney, CITED1 expression is seen in the cytoplasmic compartment. In WT, expression of CITED1 is detected in the nuclear compartment of tumor cells.1-4 It has been suggested that persistent expression of CITED1 in the MM could play a role in WT initiation and pathogenesis.1 CITED1 has been detected in 86.8% of WT Cases.2

Quality


IVD

IVD

IVD

RUO

Linkage

CITED1 Positive Control Slides, Product No. 424S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

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Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Certificate of Analysis

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Certificate of Origin

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