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441R-1

Sigma-Aldrich

NKX3.1 (EP356) Rabbit Monoclonal Primary Antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP356, monoclonal

description

(For In Vitro Diagnostic Use in Select Regions (See Chart))

form

buffered aqueous solution

species reactivity

human

packaging

bottle of 1.0 mL predilute (441R-17)
bottle of 7.0 mL predilute (441R-18)
vial of 0.1 mL concentrate (441R-14)
vial of 0.5 mL concentrate (441R-15)
vial of 1.0 mL concentrate (441R-16)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

isotype

IgG

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... NKX3-1(4824)

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NKX3.1 (EP356) Rabbit Monoclonal Primary Antibody

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conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

clone

EP356, monoclonal

clone

EP336, monoclonal

clone

EP381, monoclonal

clone

EP78, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

General description

NKX3.1 is a prostate-specific androgen-regulated homeobox gene located on chromosome8p.1-2 NKX3.1 expression is seen in benign and malignant prostate epithelium. NKX3.1is a sensitive and specific tissue marker that can be used to help identify prostateadenocarcinoma.

Quality


IVD
IVD
IVD
RUO

Linkage

NKX3.1 Positive Control Slides, Product No. 441S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Rebecca J Asch-Kendrick et al.
Journal of clinical pathology, 67(9), 768-771 (2014-07-06)
NKX3.1 is an androgen-regulated tumour suppressor gene that is downregulated in prostate carcinoma. Immunohistochemistry for NKX3.1 is primarily specific for prostatic-derived tumours and tissue but is reported in a small number of breast carcinomas. NKX3.1 is also shown to inhibit
Bora Gurel et al.
The American journal of surgical pathology, 34(8), 1097-1105 (2010-07-01)
NKX3.1 is a prostatic tumor suppressor gene located on chromosome 8p. Although most studies have shown that staining for NKX3.1 protein is positive in the majority of primary prostatic adenocarcinomas, it has been shown to be downregulated in many high-grade
Ai-Ying Chuang et al.
The American journal of surgical pathology, 31(8), 1246-1255 (2007-08-02)
The histologic distinction between high-grade prostate cancer and infiltrating high-grade urothelial cancer may be difficult, and has significant implications because each disease may be treated very differently (ie, hormone therapy for prostate cancer and chemotherapy for urothelial cancer). Immunohistochemistry of

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