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442R-1

Sigma-Aldrich

LEF1 (EP310) Rabbit Monoclonal Primary Antibody

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Synonym(s):
Lymphoid Enhancing Factor 1

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP310, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (442R-14)
vial of 0.1 mL concentrate Research Use Only (442R-14-RUO)
vial of 0.5 mL concentrate (442R-15)
vial of 1.0 mL concentrate (442R-16)
vial of 1.0 mL concentrate Research Use Only (442R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (442R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (442R-17)
vial of 7.0 mL pre-dilute ready-to-use (442R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (442R-18-RUO)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

small lymphocytic lymphoma, tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... LEF1(51176)

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This Item
328R-1AV32404MAB3749
clone

EP310, monoclonal

clone

EPR3158Y, monoclonal

clone

polyclonal

clone

3A12, monoclonal

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

species reactivity

human

species reactivity

human

species reactivity

human, dog, bovine, goat

species reactivity

human

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

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General description

Lymphoid Enhancing Factor 1 (LEF1) is a transcription factor that belongs to the TCF/LEF family. LEF1 participates as a regulator in Wnt signaling pathways. LEF1 is an important factor in lymphopoiesis and is expressed normally in T and pro-B cells but not expressed in mature B cells. Strong nuclear expression of LEF1 has been observed in majority of chronic lymphocytic leukemia/small lymphocytic lymphoma cases and LEF1 is not detected in other small B cell lymphomas. Anti-LEF1 may be used as an aid for differentiation of chronic lymphocytic leukemia/small lymphocytic lymphoma from other small B cell lymphomas.

Quality


IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Bevan Tandon et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(11), 1433-1443 (2011-06-21)
Lymphoid-enhancer-binding factor 1 (LEF1), coupling with β-catenin, functions as a key nuclear mediator of WNT/β-catenin signaling, which regulates cell proliferation and survival. LEF1 has an important role in lymphopoiesis, and is normally expressed in T and pro-B cells but not
Rajesh Kumar Gandhirajan et al.
Neoplasia (New York, N.Y.), 12(4), 326-335 (2010-04-03)
Lymphoid enhancer factor-1 (lef-1) is overexpressed in B-cell chronic lymphocytic leukemia (CLL) when compared with normal B cells and transcribes several genes implicated in the pathogenesis of CLL. We therefore hypothesize that antagonism of lef-1 might lead to killing of
Kata Boras-Granic et al.
Developmental biology, 295(1), 219-231 (2006-05-09)
Inductive reciprocal signaling between mesenchymal and adjacent epithelia gives rise to skin appendages such as hair follicles and mammary glands. Lef1-mediated canonical Wnt signaling is required for morphogenesis of these skin appendages during embryogenesis. In order to define the role

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