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44714

Sigma-Aldrich

(S)-Mevalonic acid lithium salt

≥96.0% (GC)

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Synonym(s):
Lithium (S)-3,5-dihydroxy-3-methyl-pentanoate, Lithium (S)-3,5-dihydroxy-3-methyl-valerate, S-MVA-Li
Empirical Formula (Hill Notation):
C6H12O4 · xLi+
CAS Number:
32451-23-3
Molecular Weight:
148.16 (free acid basis)

Quality Level

100

Assay

≥96.0% (GC)

optical activity

[α]/D +25.0±3.0°, c = 0.1 in 1 M HCl

storage temp.

2-8°C

InChI

1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/t6-/m0/s1

InChI key

KJTLQQUUPVSXIM-LURJTMIESA-N

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This Item
904695083875406
(S)-Mevalonic acid lithium salt ≥96.0% (GC)

Sigma-Aldrich

44714

(S)-Mevalonic acid lithium salt

(RS)-Mevalonic acid lithium salt ≥96.0% (GC)

Sigma-Aldrich

90469

(RS)-Mevalonic acid lithium salt

(R)-Mevalonic acid lithium salt ≥93.0% (qNMR)

Sigma-Aldrich

50838

(R)-Mevalonic acid lithium salt

L-Ribonic acid lithium salt ≥95.0% (TLC)

Sigma-Aldrich

75406

L-Ribonic acid lithium salt

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

optical activity

[α]/D +25.0±3.0°, c = 0.1 in 1 M HCl

optical activity

-

optical activity

[α]/D -26±3°, c = 0.1 in 0.1 M HCl (16 h)

optical activity

[α]/D -6.5±1.0°, 24 hr, c = 1 in 1 M HCl

Biochem/physiol Actions

Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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R A Larson et al.
Blood, 64(1), 257-262 (1984-07-01)
Mevalonic acid can stimulate leukemic cells from some patients with B cell chronic lymphocytic leukemia (CLL) to enter the cell cycle in vitro and to synthesize DNA. Unlike normal human peripheral blood lymphocytes, which require the presence of granulocytes for
R R Kopito et al.
Journal of lipid research, 23(4), 577-583 (1982-05-01)
A circadian rhythm in plasma mevalonate was identified in human subjects. This variation, over a 5-fold range, is paralleled by a rhythm in urinary excretion. No such diurnal change in plasma mevalonate was observed in schedule-fed, light-cycled rats, despite the
Le-Le Hu et al.
PloS one, 6(12), e29491-e29491 (2012-01-06)
Given a compound, how can we effectively predict its biological function? It is a fundamentally important problem because the information thus obtained may benefit the understanding of many basic biological processes and provide useful clues for drug design. In this
Priti Agarwal et al.
The Journal of investigative dermatology, 135(4), 1080-1088 (2014-12-19)
Vitiligo is a common autoimmune disease of the skin that results in disfiguring white spots. There are no Food and Drug Administration (FDA)-approved treatments, and current treatments are time-consuming, expensive, and of low efficacy. We sought to identify new treatments

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