Epoxide Hydrolase from Rhodococcus rhodochrous

lyophilized powder, beige, ≥0.2 U/g

CAS Number:
Enzyme Commission number:
MDL number:


lyophilized powder

Quality Level

specific activity

≥0.2 U/g



storage temp.


Biochem/physiol Actions

Epoxide hydrolase is an enantioselective catalyst for the hydrolytic kinetic resolution of epoxides.

Unit Definition

1 U corresponds to the amount of enzymes which hydrolizes 1 μmol (S)-NEPC [(2S,3S)-trans-3-phenyl-2-oxiranylmethyl-4-nitrophenyl carbonate, Prod. No. 04088] per minute at pH 8.0 and 25 °C

Other Notes

Asymmetric hydrolysis of epoxides to optically active diols

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

E N Jacobsen
Accounts of chemical research, 33(6), 421-431 (2000-07-13)
The discovery of the metal salen-catalyzed asymmetric ring-opening (ARO) of epoxides is chronicled. A screening approach was adopted for the identification of catalysts for the addition of TMSN(3) to meso-epoxides, and the chiral (salen)CrN(3) complex was identified as optimal. Kinetic...
Mischitz, M., et al.
Tetrahedron Asymmetry, 7, 2041-2041 (1996)
Hechtberger, P.
Tetrahedron Asymmetry, 4, 1161-1161 (1993)
Zhuo Shao et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(3), 581-586 (2014-01-25)
Regulation of angiogenesis is critical for many diseases. Specifically, pathological retinal neovascularization, a major cause of blindness, is suppressed with dietary ω3-long-chain polyunsaturated fatty acids (ω3LCPUFAs) through antiangiogenic metabolites of cyclooxygenase and lipoxygenase. Cytochrome P450 epoxygenases (CYP2C8) also metabolize LCPUFAs...
Ana W Y Cheong et al.
Biology of reproduction, 81(1), 126-132 (2009-03-27)
Somatic cell-embryo coculture enhances embryo development in vitro by producing embryotrophic factor(s) and/or removing harmful substances from the culture environment. Yet, the underlying molecular mechanisms on how somatic cells remove the toxicants from the culture medium remain largely unknown. By...

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