45299

Sigma-Aldrich

Epoxide Hydrolase from Rhodococcus rhodochrous

lyophilized powder, beige, ≥0.2 U/g

CAS Number:
Enzyme Commission number:
MDL number:
NACRES:
NA.54

form

lyophilized powder

Quality Level

specific activity

≥0.2 U/g

color

beige

storage temp.

2-8°C

Biochem/physiol Actions

Epoxide hydrolase is an enantioselective catalyst for the hydrolytic kinetic resolution of epoxides.

Unit Definition

1 U corresponds to the amount of enzymes which hydrolizes 1 μmol (S)-NEPC [(2S,3S)-trans-3-phenyl-2-oxiranylmethyl-4-nitrophenyl carbonate, Prod. No. 04088] per minute at pH 8.0 and 25 °C

Other Notes

Asymmetric hydrolysis of epoxides to optically active diols

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

E N Jacobsen
Accounts of chemical research, 33(6), 421-431 (2000-07-13)
The discovery of the metal salen-catalyzed asymmetric ring-opening (ARO) of epoxides is chronicled. A screening approach was adopted for the identification of catalysts for the addition of TMSN(3) to meso-epoxides, and the chiral (salen)CrN(3) complex was identified as optimal. Kinetic...
Mischitz, M., et al.
Tetrahedron Asymmetry, 7, 2041-2041 (1996)
Hechtberger, P.
Tetrahedron Asymmetry, 4, 1161-1161 (1993)
Zhuo Shao et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(3), 581-586 (2014-01-25)
Regulation of angiogenesis is critical for many diseases. Specifically, pathological retinal neovascularization, a major cause of blindness, is suppressed with dietary ω3-long-chain polyunsaturated fatty acids (ω3LCPUFAs) through antiangiogenic metabolites of cyclooxygenase and lipoxygenase. Cytochrome P450 epoxygenases (CYP2C8) also metabolize LCPUFAs...
Ana W Y Cheong et al.
Biology of reproduction, 81(1), 126-132 (2009-03-27)
Somatic cell-embryo coculture enhances embryo development in vitro by producing embryotrophic factor(s) and/or removing harmful substances from the culture environment. Yet, the underlying molecular mechanisms on how somatic cells remove the toxicants from the culture medium remain largely unknown. By...

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