46133

Supelco

Chlortetracycline hydrochloride

VETRANAL®, analytical standard

Synonym(s):
7-Chlorotetracycline hydrochloride
Empirical Formula (Hill Notation):
C22H23ClN2O8 · HCl
CAS Number:
Molecular Weight:
515.34
Beilstein/REAXYS Number:
3858364
EC Number:
MDL number:
PubChem Substance ID:
E Number:
E702
NACRES:
NA.24

Quality Level

grade

analytical standard

Agency/Method

EPA 1694

product line

VETRANAL®

form

neat

shelf life

limited shelf life, expiry date on the label

application(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

210-215 °C (dec.) (lit.)

Featured Industry

Cleaning Products
Clinical
Cosmetics
Environmental
Food and Beverages
Forensics and Toxicology
Personal Care
Pharmaceutical (small molecule)

Mode of action

protein synthesis | interferes

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

format

neat

storage temp.

2-8°C

SMILES string

Cl.CN(C)[C@H]1[C@@H]2CC3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O

InChI

1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7?,8-,15-,21-,22-;/m0./s1

InChI key

CBHYYLPALVVVEY-LYNLVHCPSA-N

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General description

Chemical structure: tetracycline

Legal Information

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

Pictograms

Exclamation markHealth hazard

Signal Word

Warning

Target Organs

Respiratory system

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Luxi Dong et al.
Chemosphere, 89(1), 44-51 (2012-06-01)
DNA damage and changes in enzyme activities were used as biomarkers to evaluate the genotoxicity and oxidative stress of tetracycline and chlortetracycline on the earthworm Eisenia fetida. The results showed that both antibiotics induced significant genotoxicity on earthworms in a...
Hui Fu et al.
Wei sheng yan jiu = Journal of hygiene research, 41(2), 282-286 (2012-05-23)
To develop a method for determination of the Metronidazole, Chlortetracycline hydrochloride, Oxytetracycline dihydrate, Minocycline hydrochloride, Erythromycin and Tetracycline hydrochloride in disinfection products by high performance liquid chromatography tandem mass spectrometry(LC-MS/MS). Samples were extracted by methanol and filtered through 0.45 microm...
V V Shepelevich et al.
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 74(6), 24-28 (2013-01-09)
Examination of sensitivity of 10 Pseudomonas chlororaphis strains belonging to different subspecies to 54 antibiotics has shown that all studied representatives of Pchlororaphis subsp. chlororaphis, P. chlororaphis subsp. aureofaciens and Pchlororaphis subsp. aurantiaca were sensitive to aminoglycoside antibiotics and fluoroquinolones...
Hyeon Young Kim et al.
Bulletin of environmental contamination and toxicology, 89(2), 234-239 (2012-06-08)
The purpose of this study was to examine the effects of veterinary antibiotics, including amoxicillin (AMX), chlortetracycline (CTC) and tylosin (TYL), on the biochemical mechanism of human embryonic kidney cells (HEK293). CTC and TYL inhibited HEK293 cell proliferation, in both...
Dasong Lin et al.
Environmental pollution (Barking, Essex : 1987), 171, 46-51 (2012-08-08)
This study aims to evaluate toxic effects of exposure to chlortetracycline (CTC) in soil on reproductive endpoints (juvenile counts and cocoon counts), biochemical responses, and genotoxic potentials of the earthworm Eisenia fetida. Results showed that juvenile counts and cocoon counts...

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