MilliporeSigma
  • 483R1
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483R-1

Sigma-Aldrich

p40 (ZR8) Rabbit Monoclonal Antibody

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

ZR8

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (483R-14)
vial of 0.1 mL concentrate, Research Use Only (483R-14-RUO)
vial of 0.5 mL concentrate (483R-15)
vial of 1.0 mL concentrate (483R-16)
vial of 1.0 mL concentrate, Research Use Only (483R-16-RUO)
vial of 1.0 mL pre-dilute, Research Use Only (483R-17-RUO)
vial of 1.0 mL pre-dilute, ready to use (483R-17)
vial of 25.0 mL pre-dilute, ready-to-use (483R-10)
vial of 25.0 mL pre-dilute, ready-to-use, Research Use Only (483R-10-RUO)
vial of 7.0 mL pre-dilute, ready to use (483R-18)
vial of 7.0 mL pre-dilute, ready to use, Research Use Only (483R-18-RUO)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (1:100-1:200 (concentrated))

isotype

IgG

control

lung (squamous cell carcinoma), prostate, urothelial carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

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biological source

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conjugate

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conjugate

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conjugate

unconjugated

antibody form

culture supernatant

antibody form

purified antibody

antibody form

purified antibody

antibody form

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clone

ZR8

clone

11F12.1, monoclonal

clone

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clone

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form

buffered aqueous solution

form

-

form

-

form

buffered aqueous solution

species reactivity

human

species reactivity

human, mouse

species reactivity

mouse, human

species reactivity

human

General description

p40 is an isoform of p63, a transcription factor that regulates many cell activities, including cell proliferation, maintenance, and differentiation. It performs as a sensitive and specific tool for aiding in the identification of squamous cell carcinoma of the lung. In addition to its utility as a squamous differentiation marker, p40 has also been proven to be a valuable marker for highlighting myoepithelial and basal cell populations in prostate, breast, skin, and salivary gland.1-5 Strong p40 expression is frequently observed in esophageal cancerous squamous lesions.6 Immunohistochemical detection of p40 can also be helpful in identifying urothelial carcinoma.7 In cases of prostate carcinoma, p40 is almost always found to be negative for basal cell staining.8

Quality

  • United States - IVD
  • Canada - RUO
  • European Union - IVD
  • Japan - RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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