All Photos(1)

Documents

COO/COA

490M-1

Tyrosine Hydroxylase (LNC1) Mouse Monoclonal Antibody

All Photos(1)

Synonym(s):

TYH

biological source

(Mouse)

Quality Level

500

conjugate

unconjugated

antibody form

(IgG1 Supernatant)

antibody product type

primary antibodies

clone

LNC1

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL (concentrate (490M-14))
vial of 0.1 mL (concentrate (490M-14-RUO) Research Use Only)
vial of 0.5 mL (concentrate (490M-15))
vial of 1.0 mL (concentrate (490M-16))
vial of 1.0 mL (concentrate (490M-16-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute (490M-17-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute ready-to-use (490M-17))
vial of 7.0 mL (pre-dilute ready-to-use (490M-18))
vial of 7.0 mL (pre-dilute ready-to-use (490M-18-RUO) Research Use Only)

manufacturer/tradename

Cell Marque^™

technique(s)

immunohistochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:25-1:100 (concentrated))

isotype

IgG1

control

neuroblastoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	IHCR1005-6	344M-9	MAB318-AF488
490M-1 Tyrosine Hydroxylase (LNC1) Mouse Monoclonal Antibody	Sigma-Aldrich IHCR1005-6 Anti-Tyrosine Hydroxylase Antibody, prediluted, clone LNC1	Sigma-Aldrich 344M-9 Tyrosinase (T311) Mouse Monoclonal Antibody	Sigma-Aldrich MAB318-AF488 Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor^™ 488 Conjugate
conjugate unconjugated	conjugate -	conjugate unconjugated	conjugate ALEXA FLUOR^™ 488
antibody form (IgG1 Supernatant)	antibody form purified antibody	antibody form diluted ascites fluid	antibody form purified antibody
clone LNC1	clone LNC1, monoclonal	clone T311, monoclonal	clone LNC1, monoclonal
form buffered aqueous solution	form -	form buffered aqueous solution	form -
species reactivity human	species reactivity monkey, lizard, mouse, human, zebrafish, vole, frog, rat, chicken	species reactivity human	species reactivity human, chicken, mouse, frog, zebrafish, rat

General description

Tyrosine Hydroxylase (TYH) is the rate-limiting enzyme of catecholamine biosynthesiss. TYH uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-DOPA, a precursor to dopamine. Anti-TYH is sensitive and specific for peripheral neuroblastic tumors in the differential diagnosis from other tumors of childhood and shows high diagnostic utility. Anti-TYH has been shown to positively label all pheochromocytomas and sympathetic paragangliomas, and thus aids in differentiating them from their histologic mimics such as adrenocortical neoplasms.

Quality

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

How to Find the Product Number

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (Example: T1503).

Example:

T1503

Product Number

25G

Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

How to Find a Lot/Batch Number for COA

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').
For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').
For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

HuC/D expression in small round cell tumors and neuroendocrine tumors: a useful tool for distinguishing neuroblastoma from childhood small round cell tumors.

Junkichi Takemoto et al.

Human pathology, 85, 162-167 (2018-11-24)

The RNA-binding protein HuC/D displays a neuron-specific expression and is involved in neuronal differentiation and the maintenance of the nervous system. Here we investigated the diagnostic value of HuC/D in neuroblastomas. We evaluated 85 neuroblastic tumors: 81 neuroblastomas; 3 ganglioneuroblastomas

Effect of inhibition of catecholamine synthesis on central catecholamine-containing neurones in the developing albino rat.

L A Loizou

British journal of pharmacology, 41(1), 41-48 (1971-01-01)

1. Tyrosine hydroxylase is thought to be the rate limiting enzyme step in catecholamine biosynthesis. Inhibition of this enzyme using alpha-methyl-p-tyrosine resulted in a time dependent depletion (and repletion) of formaldehyde induced fluorescence in catecholamine-containing neurones of the central nervous

Tyrosine hydroxylase and regulation of dopamine synthesis.

S Colette Daubner et al.

Archives of biochemistry and biophysics, 508(1), 1-12 (2010-12-24)

Tyrosine hydroxylase is the rate-limiting enzyme of catecholamine biosynthesis; it uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its amino terminal 150 amino acids comprise a domain whose structure is involved in regulating the enzyme's activity. Modes of

Utility of Phox2b immunohistochemical stain in neural crest tumours and non-neural crest tumours in paediatric patients.

Mikako Warren et al.

Histopathology, 72(4), 685-696 (2017-10-08)

This study evaluated the utility of Phox2b in paediatric tumours. Previously, tyrosine hydroxylase (TH) was the most widely utilised sympathoadrenal marker specific for neural crest tumours with neuronal/neuroendocrine differentiation. However, its sensitivity is insufficient. Recently Phox2b has emerged as another

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service