50239

Gly-Gly-Gly

≥99.0% (NT), suitable for ligand binding assays, BioUltra

• Synonym(s): Glycyl-glycyl-glycine, Triglycine
• Linear Formula: NH₂CH₂CONHCH₂CONHCH₂COOH
• CAS Number: 556-33-2
• Molecular Weight: 189.17
• Beilstein/REAXYS Number: 1711130
• EC Number: 209-122-0
• MDL number: MFCD00036223
• UNSPSC Code: 12352209
• PubChem Substance ID: 57651245
• NACRES: NA.26

Properties

• Product Name: Gly-Gly-Gly, BioUltra, ≥99.0% (NT)
• product line: BioUltra
• assay: ≥99.0% (NT)
• form: powder
• technique(s): ligand binding assay: suitable
• impurities: insoluble matter, passes filter test
• ign. residue: ≤0.1% (as SO₄)
• loss: ≤0.5% loss on drying, 110 °C
• color: white
• pH: 4.5-6.0 (25 °C, 0.5 M in H₂O)
• solubility: H₂O: 0.5 M at 20 °C, clear, colorless
• anion traces: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• cation traces: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤50 mg/kg; Bi: ≤5 mg/kg; Ca: ≤20 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• λ: 0.5 M in H₂O
• UV absorption: λ: 260 nm A_max: 0.15; λ: 280 nm A_max: 0.10
• SMILES string: NCC(=O)NCC(=O)NCC(O)=O
• InChI: 1S/C6H11N3O4/c7-1-4(10)8-2-5(11)9-3-6(12)13/h1-3,7H2,(H,8,10)(H,9,11)(H,12,13)
• InChI key: XKUKSGPZAADMRA-UHFFFAOYSA-N

Description

Amino Acid Sequence

Gly-Gly-Gly

General description

Gly-Gly-Gly or triglycine is a flexible peptide linker[1] with three glycine residues linked by peptide bonds in a linear sequence. Gly-linkers link multiple domains in a single protein without affecting the function of each domain.[1]

Application

<ul>
<li><strong>Targeting PEPT1: a novel strategy to improve the antitumor efficacy of doxorubicin in human hepatocellular carcinoma therapy:</strong> Research explores Gly-Gly-Gly peptides as potential enhancers for drug transport efficiency, positioning them as valuable tools in clinical diagnostic peptide development for targeted cancer therapies (Gong et al., 2017).</li>
<li><strong>Iminopyridine complexes of manganese, rhenium, and molybdenum derived from amino ester methylserine and peptides Gly-Gly, Gly-Val, and Gly-Gly-Gly: self-assembly of the peptide chains:</strong> This study demonstrates the use of Gly-Gly-Gly in the synthesis of complex metal-peptide frameworks for potential use in high-purity peptide applications in IVD manufacturing (&Aacute;lvarez et al., 2012).</li>
</ul>

Biochem/physiol Actions

Substrate for reproducible serum protein measurements by the biuret reaction and for the assay of aminotripeptidases.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)