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57600

Sigma-Aldrich

Interleukin-2 human

recombinant, expressed in E. coli, ~10000 U/mL

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Synonym(s):
IL-2, TCGF, hIL-2
CAS Number:
MDL number:
NACRES:
NA.32

biological source

human

Quality Level

recombinant

expressed in E. coli

form

liquid

mol wt

Mr ~15500

packaging

vial of 1 mL

concentration

~10000 U/mL

color

colorless

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... IL2(3558)

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This Item
I7908I2644SRP3085
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57600

Interleukin-2 human

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I7908

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I2644

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SRP3085

Interleukin-2, human

recombinant

expressed in E. coli

recombinant

expressed in Pichia pastoris

recombinant

expressed in E. coli

recombinant

expressed in E. coli

form

liquid

form

lyophilized powder

form

lyophilized powder

form

lyophilized

mol wt

Mr ~15500

mol wt

predicted mol wt ~15 kDa

mol wt

15.5 kDa

mol wt

15.5 kDa

packaging

vial of 1 mL

packaging

pkg of 10KU

packaging

pkg of 5X10 μg, pkg of 10 μg

packaging

pkg of 50 μg

concentration

~10000 U/mL

concentration

-

concentration

-

concentration

-

Biochem/physiol Actions

Promotes the growth of IL-2 dependent lymphocytes. Amino acid sequence of IL-2.

Packaging

One vial contains 10′000 Units

Caution

Stable at −20 °C; prepare appropriate aliquots and avoid repeated freezing and thawing, since aggregation may occur resulting in apparent loss of activity.

Unit Definition

1 U corresponds to the unit activity in the colorimetric MTT-assay with CTLL-2 cells.

Physical form

Clear; colorless solution in Dulbecco-PBS; containing 1 mg BSA/mL.

Other Notes

Sales restrictions may apply.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Interleukin 2.
K A Smith
Annual review of immunology, 2, 319-333 (1984-01-01)
S Gillis et al.
Journal of immunology (Baltimore, Md. : 1950), 120(6), 2027-2032 (1978-06-01)
Several soluble factors have recently been associated with the proliferation and differentiation of thymus-derived lymphocytes. One of these factors present in medium conditioned by T cell mitogen-stimulated lymphocytes has the ability to promote the long-term culture of normal and antigen-specific
R J Robb et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(20), 6486-6490 (1984-10-01)
Human interleukin 2 was separated into multiple molecular forms by selective immunoaffinity chromatography and chromatofocusing. For the most part, this heterogeneity was attributed to variations in glycosylation of the threonine residue in position 3 of the polypeptide chain. The various
Cecilie Brekke Rygh et al.
PloS one, 9(9), e108414-e108414 (2014-10-01)
There are currently no established radiological parameters that predict response to immunotherapy. We hypothesised that multiparametric, longitudinal magnetic resonance imaging (MRI) of physiological parameters and pharmacokinetic models might detect early biological responses to immunotherapy for glioblastoma targeting NG2/CSPG4 with mAb9.2.27
Nabil Ahmed et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33(15), 1688-1696 (2015-03-25)
The outcome for patients with metastatic or recurrent sarcoma remains poor. Adoptive therapy with tumor-directed T cells is an attractive therapeutic option but has never been evaluated in sarcoma. We conducted a phase I/II clinical study in which patients with

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