57600

Sigma-Aldrich

Interleukin-2 human

recombinant, expressed in E. coli, ~10000 U/mL

Synonym(s):
IL-2, hIL-2, TCGF
CAS Number:
MDL number:
NACRES:
NA.32

Quality Level

biological source

human

recombinant

expressed in E. coli

form

liquid

mol wt

Mr ~15500

packaging

vial of 1 mL

concentration

~10000 U/mL

color

colorless

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... IL2(3558)

Biochem/physiol Actions

Promotes the growth of IL-2 dependent lymphocytes. Amino acid sequence of IL-2.

Packaging

One vial contains 10′000 Units

Caution

Stable at −20 °C; prepare appropriate aliquots and avoid repeated freezing and thawing, since aggregation may occur resulting in apparent loss of activity.

Unit Definition

1 U corresponds to the unit activity in the colorimetric MTT-assay with CTLL-2 cells.

Physical form

Clear; colorless solution in Dulbecco-PBS; containing 1 mg BSA/mL.

Other Notes

Sales restrictions may apply.

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

S Gillis et al.
Journal of immunology (Baltimore, Md. : 1950), 120(6), 2027-2032 (1978-06-01)
Several soluble factors have recently been associated with the proliferation and differentiation of thymus-derived lymphocytes. One of these factors present in medium conditioned by T cell mitogen-stimulated lymphocytes has the ability to promote the long-term culture of normal and antigen-specific...
Interleukin 2.
K A Smith
Annual review of immunology, 2, 319-333 (1984-01-01)
R J Robb et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(20), 6486-6490 (1984-10-01)
Human interleukin 2 was separated into multiple molecular forms by selective immunoaffinity chromatography and chromatofocusing. For the most part, this heterogeneity was attributed to variations in glycosylation of the threonine residue in position 3 of the polypeptide chain. The various...
Denise L Cecil et al.
Cancer research, 74(10), 2710-2718 (2014-04-30)
Immunization against self-tumor antigens can induce T-regulatory cells, which inhibit proliferation of type I CD4(+) T-helper (TH1) and CD8(+) cytotoxic T cells. Type I T cells are required for potent antitumor immunity. We questioned whether immunosuppressive epitopes could be identified...
Katrien Van Raemdonck et al.
Angiogenesis, 17(3), 631-640 (2014-01-29)
CXC chemokines influence a variety of biological processes, such as angiogenesis, both in a physiological and pathological context. Platelet factor-4 (PF-4)/CXCL4 and its variant PF-4var/CXCL4L1 are known to favor angiostasis by inhibiting endothelial cell proliferation and chemotaxis. CXCL4L1 in particular...

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