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61326

Sigma-Aldrich

Lactoferrin from human milk

~80% (GE)

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CAS Number:
936541-36-5
MDL number:
MFCD00164307
NACRES:
NA.61

biological source

human milk

Quality Level

100

Assay

~80% (GE)

form

solid

mol wt

82.4 kDa

solubility

H2O: 1 mg/mL, clear to very faintly hazy, colorless to faintly yellow

cation traces

Fe: ≤400 mg/kg

UniProt accession no.

P02788

storage temp.

2-8°C

InChI

1S/C35H53N9O12/c1-16(2)27(43-33(53)23(14-26(47)48)41-25(46)15-38-29(49)18(5)39-31(51)21(36)13-24(37)45)34(54)40-19(6)30(50)42-22(12-20-10-8-7-9-11-20)32(52)44-28(17(3)4)35(55)56/h7-11,16-19,21-23,27-28H,12-15,36H2,1-6H3,(H2,37,45)(H,38,49)(H,39,51)(H,40,54)(H,41,46)(H,42,50)(H,43,53)(H,44,52)(H,47,48)(H,55,56)/t18-,19-,21-,22-,23-,27-,28-/m0/s1

InChI key

QCBUWCQOKPLTDZ-PKRULZLPSA-N

Gene Information

human ... LTF(4057)

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This Item
L0520SRP6519L3770
Sigma-Aldrich

Sigma-Aldrich

61326

Lactoferrin from human milk

Lactoferrin from human milk ≥85% (SDS-PAGE), lyophilized powder

Sigma-Aldrich

L0520

Lactoferrin from human milk

Lactoferrin from human milk ≥95% (SDS-PAGE)

Sigma-Aldrich

SRP6519

Lactoferrin from human milk

Lactoferrin from human milk Iron saturated, ≥85% (SDS-PAGE)

Sigma-Aldrich

L3770

Lactoferrin from human milk

assay

~80% (GE)

assay

≥85% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥85% (SDS-PAGE)

form

solid

form

lyophilized powder

form

frozen liquid

form

powder

mol wt

82.4 kDa

mol wt

82.4 kDa

mol wt

82.4 kDa

mol wt

82.4 kDa

solubility

H2O: 1 mg/mL, clear to very faintly hazy, colorless to faintly yellow

solubility

phosphate buffer: 1 mg/mL, clear to slightly hazy (0.01 M phosphate buffer, 0.0027 M potassium chloride and 0.137 M sodium chloride, pH 7.4, at 25 °C)

solubility

-

solubility

phosphate buffer: 10 mg/mL at 25 °C (0.01 M phosphate buffer, 0.0027 M potassium chloride and 0.137 M sodium chloride, pH 7.4)

UniProt accession no.

P02788

UniProt accession no.

P02788

UniProt accession no.

4057

UniProt accession no.

P02788

Application

Lactoferrin was used for development of lactoferrin immunosensor.

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Luigi Campanella et al.
Journal of pharmaceutical and biomedical analysis, 53(2), 186-193 (2010-04-17)
The last year we fabricated some new immunosensors for the analysis of lactoferrin protein. In the present research the immunological and analytical characteristics of the immunosensor method have been extensively investigated. The study was therefore extended to cover the ability
Gregory T Spear et al.
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