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Sigma-Aldrich

N-Lauroylsarcosine sodium salt

BioUltra, for molecular biology, ≥99.0% (HPLC)

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Synonym(s):
N-lauroylsarcosine sodium salt, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL
Linear Formula:
CH3(CH2)10CON(CH3)CH2COONa
CAS Number:
Molecular Weight:
293.38
Beilstein/REAXYS Number:
5322974
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

grade

for molecular biology

Quality Level

description

anionic

product line

BioUltra

assay

≥99.0% (HPLC)

form

powder

mol wt

micellar avg mol wt 600
average mol wt 600

aggregation number

2

impurities

DNases, none detected
RNases, none detected
insoluble matter, passes filter test
phosphatases, none detected
proteases, none detected

loss

≤1% loss on drying, 110 °C

pH

7.0-9.0 (25 °C, 1 M in H2O)

CMC

14.6 mM (20-25°C)

solubility

H2O: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

1 M in H2O

UV absorption

λ: 260 nm Amax: 0.2
λ: 280 nm Amax: 0.06

SMILES string

[Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O

application(s)

sample preservation

InChI

1S/C15H29NO3.Na/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19;/h3-13H2,1-2H3,(H,18,19);/q;+1/p-1

Inchi Key

KSAVQLQVUXSOCR-UHFFFAOYSA-M

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General description

The N-lauroylsarcosine sodium salt is applicable for processes that require tight control of elemental content. This product aids in the solubilization and separation of membrane proteins, glycoproteins, and the isolation of RNA and plasmids. N-lauroylsarcosine sodium salt serves as an antifoaming supplement or as a component of a lysing buffer of bacteria or other cells. It indicates the paramagnetic anisotropy sign change in the micelle mesophase. N-lauroylsarcosine sodium salt inhibits hexokinase and the bacterial flora of human saliva/gut at 0.25%. It also exhibits fungistatic activity in aqueous dispersion (1%). N-lauroylsarcosine (LS) is an anionic surfactant with protein denaturant potency that is structurally similar to sodium lauryl sulfate (SLS). It can inactivate herpes simplex virus (HSV) infectivity in vitro. It is used as a microbicide in topical vaginal formulations to block the transmission of HSV, human immunodeficiency virus type 1 (HIV-1), and possibly other pathogens causing sexually transmitted diseases (STDs).

Application

N-Lauroylsarcosine sodium salt has been used as a component:

  • of nuclease stop mix, embryo extract buffer to dissociate nonspecifically bound proteins from chromatin
  • of proteinase K solution for the heat denaturation of genomic DNA
  • of 10% (w/v) sarcosyl/0.5 M ethylenediaminetetraacetic acid (EDTA) solution to prepare EDTA-sarcosyl-proteinase (ESP) buffer
  • in the hybridization buffer for in situ hybridization histochemistry
  • in the embryo extract buffer to dissociate nonspecifically bound proteins from chromatin
  • in proteinase K solution to inactivate the enzymes

Other Notes

Anionic surfactant.

pictograms

CorrosionSkull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Eye Dam. 1 - Skin Irrit. 2

Storage Class

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 1

flash_point_f

512.6 °F - closed cup

flash_point_c

267 °C - closed cup

ppe

Eyeshields, Gloves, type N95 (US)


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The mechanisms of herpes simplex virus (HSV) inactivation by sodium lauryl sulfate (SLS) and n-lauroylsarcosine (LS), two anionic surfactants with protein denaturant potency, have been evaluated in cultured cells. Results showed that pretreatment of HSV type 1 (HSV-1) strain F

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