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Dextran sulfate sodium salt

Name: Dextran sulfate sodium salt
Brand: SIGMA

Synonym(s):

Dextran Sulfate Sodium

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About This Item

NACRES:

NA.25

UNSPSC Code:

12352201

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Properties

form

powder

Quality Level

200

loss

≤10% loss on drying

useful pH range

6.0-8.0 (10 g/L)

solubility

H₂O: 100 mg/mL, colorless to faintly greenish-yellow

storage temp.

room temp

Description

General description

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.

Application

Dextran sulfate is routinely used for the selective precipitation of lipoproteins, probe hybridization membrane-immobilized DNA, the release of DNA from DNA-histone complexes, and the inhibition of RNA binding to ribosomes.

Dextran sulfate is used as a diluent in in situ hybridization experiments to increase hybridization of probes to target sequences in tissues.[1]

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

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This Item	51227	75027	42867
Sigma-Aldrich 67578 Dextran sulfate sodium salt	Sigma-Aldrich 51227 Dextran sulfate sodium salt	Sigma-Aldrich 75027 Dextran sulfate sodium salt	Sigma-Aldrich 42867 Dextran sulfate sodium salt
Quality Level 200	Quality Level 100	Quality Level -	Quality Level 100
solubility H₂O: 100 mg/mL, colorless to faintly greenish-yellow	solubility H₂O: 100 mg/mL, clear, colorless to faintly greenish-yellow	solubility H₂O: 100 mg/mL, clear, colorless to faintly greenish-yellow	solubility water: soluble
form powder	form powder	form powder	form powder
storage temp. room temp	storage temp. room temp	storage temp. room temp	storage temp. room temp
useful pH range 6.0-8.0 (10 g/L)	useful pH range 6.0-8 (10 g/L)	useful pH range 6.0-8.0 (10 g/L)	useful pH range 6.0-8 (10 g/L)
loss ≤10% loss on drying	loss ≤10% loss on drying	loss ≤10% loss on drying	loss ≤10% loss on drying

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Articles

Pharmaceutical Research Applications of Carbohydrates and Polysaccharides

Discover the role of carbohydrates in drug delivery, from solubility and stability improvement to advanced controlled-release systems.

Carbohydrates as Versatile Enablers of Advanced Drug Delivery Systems

Explore how carbohydrates function as excipients and carriers in drug delivery, with insights into mechanisms, case studies, and future trends.

The rate of nucleic acid annealing to cytological preparations is increased in the presence of dextran sulfate.

L L Lederman et al.

Analytical biochemistry, 117(1), 158-163 (1981-10-01)

Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner.

Sinah-Sophia Weiterer et al.

The EMBO journal, 39(1), e101533-e101533 (2019-11-09)

How cytokine-driven changes in chromatin topology are converted into gene regulatory circuits during inflammation still remains unclear. Here, we show that interleukin (IL)-1α induces acute and widespread changes in chromatin accessibility via the TAK1 kinase and NF-κB at regions that

Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.

Rodabe N Amaria et al.

Nature medicine, 24(11), 1649-1654 (2018-10-10)

Preclinical studies suggest that treatment with neoadjuvant immune checkpoint blockade is associated with enhanced survival and antigen-specific T cell responses compared with adjuvant treatment1; however, optimal regimens have not been defined. Here we report results from a randomized phase 2

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Global Trade Item Number

SKU	GTIN
67578-5G	04061832742168
67578-100G	04061832736167
67578-25G	04061832742069

Questions

1–3 of 3 Questions

Anonymous

9 months ago

How can I determine the shelf life / expiration / retest date of this product?

1 answer
1. Technical Support
  
  9 months ago
  
  If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
  For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
  For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
  For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
  
  Helpful?
11 months ago

Is there a molecular weight range specified and if not is their a rough estimate for the molecular weight range?

1 answer
1. Technical Support
  
  10 months ago
  
  The estimated molecular weight range of this product is 500,000 - 700,000 kDa.
  
  Helpful?
Anonymous

a year ago

How is shipping temperature determined? And how is it related to the product storage temperature?

1 answer
1. Technical Support
  
  a year ago
  
  Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
  
  Helpful?

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