67806

Sigma-Aldrich

Rhodol

≥85% (HPCE)

Synonym(s):
3′-Amino-6′-hydroxy-fluoran
Empirical Formula (Hill Notation):
C20H13NO4
CAS Number:
Molecular Weight:
331.32
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Quality Level

assay

≥85% (HPCE)

fluorescence

λex 492 nm; λem 516 nm in 0.1 M phosphate pH 7.0

storage temp.

2-8°C

SMILES string

Nc1ccc2c(Oc3cc(O)ccc3C24OC(=O)c5ccccc45)c1

InChI

1S/C20H13NO4/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20/h1-10,22H,21H2

InChI key

OKFGUUIODGPPLE-UHFFFAOYSA-N

Application

Rhodol and its derivatives may be used in a wide variety of molecular imaging and immunofluorescence microscopy applications. Specific Rhodol derivatives are useful as enzyme substrates.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
M Benchaib et al.
Histochemistry and cell biology, 106(2), 253-256 (1996-08-01)
Fluorescein isothiocyanate (FITC) is largely used in immunofluorescence methods. We propose to analyse the quality of some recent fluorochromes using image analysis. Fluorochromes tested include FITC and dichlorotriazinylaminofluorescein (DTAF), dipyrrometheneboron difluoride (BODIPY), Rhodol Green and cyanine 2. RAMOS cells were...
J E Whitaker et al.
Analytical biochemistry, 207(2), 267-279 (1992-12-01)
A series of chemically reactive, fluorescent rhodol derivatives was prepared and evaluated. Reactive functional groups included activated esters, amines, haloacetamides, fixable hydrazide derivatives, acrylamides, and photoaffinity reagents. Depending on the choice of substituents, absorption maxima of the dyes varied from...
Tao Peng et al.
Organic letters, 12(3), 496-499 (2010-01-14)
A highly efficient and concise synthetic scheme for rhodol fluorophores is developed with palladium-catalyzed amination reaction as the key step. This new synthetic route is utilized to construct a rhodol library, potentially useful for the design of novel fluorescent probes.
Raphael Alford et al.
Molecular imaging, 8(6), 341-354 (2009-12-17)
Fluorophores are potentially useful for in vivo cancer diagnosis. Using relatively inexpensive and portable equipment, optical imaging with fluorophores permits real-time detection of cancer. However, fluorophores can be toxic and must be investigated before they can be administered safely to...

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