72779

Triclosan

97.0-103.0% (active substance, GC)

• Synonym(s): Triclosan, 5-Chloro-2-(2,4-dichlorophenoxy)phenol, Irgasan
• Empirical Formula (Hill Notation): C₁₂H₇Cl₃O₂
• CAS Number: 3380-34-5
• Molecular Weight: 289.54
• Beilstein: 2057142
• EC Number: 222-182-2
• MDL number: MFCD00800992
• PubChem Substance ID: 57652433
• NACRES: NA.85

Properties

• biological source: synthetic
• Quality Level: 200
• assay: 97.0-103.0% (active substance, GC)
• form: powder or crystals
• impurities: ≤0.1% Water (Karl Fischer)
• color: white
• mp: 55-59 °C
• solubility: 1 M NaOH: 5% at 25 °C, faintly turbid to clear (colorless solution)
• antibiotic activity spectrum: fungi
• Mode of action: enzyme | inhibits
• SMILES string: Oc1cc(Cl)ccc1Oc2ccc(Cl)cc2Cl
• InChI: 1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
• InChI key: XEFQLINVKFYRCS-UHFFFAOYSA-N

Description

General description

Chemical structure: diphenyl ether derivative

Packaging

5, 25 g in poly bottle

Application

A component of cefsulodin-irgasan-novobiocin selection medium for Yersinia, a human pathogen that may contaminate animal-source food products. Because of its low antigenicity, irgasan is also a component of many antibacterial consumer products.

Biochem/physiol Actions

Irgasan is a broad spectrum antimicrobial agent. It is an inhibitor of the enoyl-ACP (acyl-carrier protein) reductase component of type II fatty acid synthase (FAS-II) in bacteria and Plasmodium. It also inhibits mammalian fatty acid synthase (FASN), and may have anticarcinogenic activity.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H410
• Precautionary Statements: P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves