74667

Nourseothricin sulfate

≥85% (HPLC)

• CAS Number: 96736-11-7
• MDL number: MFCD00165013
• UNSPSC Code: 51102829
• NACRES: NA.85

Properties

• biological source: Streptomyces noursei
• assay: ≥85% (HPLC)
• form: solid
• color: white to light brown
• solubility: H₂O: soluble 200 mg/mL
• suitability: suitable for (selection agent for molecular genetic research work)
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; fungi; mycobacteria; mycoplasma; parasites; viruses; yeast
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [S](=O)(=O)(O)O.N4[C@H]5[C@H](N=C4N[C@@H]6O[C@@H]([C@@H]([C@H]([C@H]6NC(=O)C[C@@H](N)CCCNC(=O)C[C@@H](N)CCCNC(=O)C[C@@H](N)CCCN)O)OC(=O)N)CO)C(=O)NC[C@H]5O.N1[C@H]2[C@H](N=C1N[C@@H]3O[C@@H]([C@@H]([C@H]([C@H]3NC(=O)C[C@@H](N)CCCN)O)OC(=O)N)CO)C(=O)NC[C@H]
• InChI key: HEPYPTBGGNPPAP-SPCBHCMPSA-N

Description

General description

Chemical structure: peptidyl nucleoside

Application

Noursethricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants.

Biochem/physiol Actions

Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin.

Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the β-amino group of the β-lysin.

Packaging

10mg, 100mg

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves