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74875

Sigma-Aldrich

8-Octanoyloxypyrene-1,3,6-trisulfonic acid trisodium salt

suitable for fluorescence, ≥90% (HPCE)

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Synonym(s):
Trisodium 8-octanoyloxypyrene-1,3,6-trisulfonate
Empirical Formula (Hill Notation):
C24H21Na3O11S3
CAS Number:
115787-84-3
Molecular Weight:
650.58
MDL number:
MFCD00037628
PubChem Substance ID:
57652536
NACRES:
NA.32

Quality Level

100

Assay

≥90% (HPCE)

form

powder

mp

251-260 °C (lit.)

solubility

DMF: soluble
DMSO: soluble
H2O: soluble
methanol: soluble

fluorescence

λex 384 nm; λem 409 nm in H2O
λex 460 nm; λem 510 nm in 0.1 M Tris pH 8.0 (esterase)

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].CCCCCCCC(=O)Oc1cc(c2ccc3c(cc(c4ccc1c2c34)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O

InChI

1S/C24H24O11S3.3Na/c1-2-3-4-5-6-7-22(25)35-18-12-19(36(26,27)28)15-10-11-17-21(38(32,33)34)13-20(37(29,30)31)16-9-8-14(18)23(15)24(16)17;;;/h8-13H,2-7H2,1H3,(H,26,27,28)(H,29,30,31)(H,32,33,34);;;/q;3*+1/p-3

InChI key

RZVSWISDVXUSGY-UHFFFAOYSA-K

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H152946935A7222
8-Octanoyloxypyrene-1,3,6-trisulfonic acid trisodium salt suitable for fluorescence, ≥90% (HPCE)

Sigma-Aldrich

74875

8-Octanoyloxypyrene-1,3,6-trisulfonic acid trisodium salt

8-Hydroxypyrene-1,3,6-trisulfonic acid trisodium salt ≥96%

Sigma-Aldrich

H1529

8-Hydroxypyrene-1,3,6-trisulfonic acid trisodium salt

6-[Fluorescein-5(6)-carboxamido]hexanoic acid suitable for fluorescence, ≥90% (HPCE)

Sigma-Aldrich

46935

6-[Fluorescein-5(6)-carboxamido]hexanoic acid

8-Aminopyrene-1,3,6-trisulfonic acid trisodium salt ≥96.0% (HPCE), solid

Sigma-Aldrich

A7222

8-Aminopyrene-1,3,6-trisulfonic acid trisodium salt

form

powder

form

-

form

solid

form

solid

solubility

DMF: soluble, DMSO: soluble, H2O: soluble, methanol: soluble

solubility

-

solubility

DMF: soluble, DMSO: soluble

solubility

-

fluorescence

λex 384 nm; λem 409 nm in H2O, λex 460 nm; λem 510 nm in 0.1 M Tris pH 8.0 (esterase)

fluorescence

λex 454 nm; λem 511 nm (pH 9.1), λex 454 nm; λem 520 nm in H2O

fluorescence

λex 491 nm; λem 515 nm in 0.1 M Tris pH 9.0

fluorescence

-

suitability

suitable for fluorescence

suitability

-

suitability

suitable for fluorescence

suitability

-

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

Application

suitable as fluorogenic substrate for esterases, lipases

Other Notes

Highly water soluble enzyme substrate for fluorimetric assay of esterases and lipases at longwave excitation and emission wavelengths

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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O S Wolfbeis et al.
Analytical biochemistry, 129(2), 365-370 (1983-03-01)
A direct and continuous kinetic method for the fluorimetric assay of various hydrolases by using new, highly water-soluble substrates is described. The latter consist of esters of strongly fluorescent 1-hydroxypyren-3,6,8-trisulfonic acid trisodium salt with acetic, butyric, caprylic, and oleic acid.
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Our collaborative successful gene replacement therapy using AAV vectors expressing a variant of human RPGR-ORF15 in two canine models provided therapeutic proof of concept for translation into human treatment. The ORF15 sequence contained within this AAV vector, however, has ORF15
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Currently there are no efficacious therapies for patients with anaplastic thyroid carcinoma (ATC) that result in long-term disease stabilization or regression. We sought to identify pathways critical for ATC cell progression and viability in an effort to develop new therapeutic
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