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75447

Sigma-Aldrich

2-Oxoadipic acid

≥95.0% (HPLC)

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Synonym(s):
α-Ketoadipic acid, 2-Oxoadipate, 2-Oxohexanedioic acid
Empirical Formula (Hill Notation):
C6H8O5
CAS Number:
Molecular Weight:
160.12
MDL number:
PubChem Substance ID:

Quality Level

Assay

≥95.0% (HPLC)
≥97.0% (T)

form

powder

lipid type

saturated FAs

storage temp.

2-8°C

SMILES string

OC(=O)CCCC(=O)C(O)=O

InChI

1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)

InChI key

FGSBNBBHOZHUBO-UHFFFAOYSA-N

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This Item
786107595045150
2-Oxoadipic acid ≥95.0% (HPLC)

Sigma-Aldrich

75447

2-Oxoadipic acid

Phenylglyoxylic acid purum, ≥98.0% (T)

Sigma-Aldrich

78610

Phenylglyoxylic acid

2-Oxovaleric acid ≥98.0% (T)

Sigma-Aldrich

75950

2-Oxovaleric acid

Pamoic acid ≥97.0% (T)

Sigma-Aldrich

45150

Pamoic acid

form

powder

form

crystals

form

liquid

form

-

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

-

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

lipid type

saturated FAs

lipid type

-

lipid type

-

lipid type

-

Biochem/physiol Actions

Important metabolite between the TCA cycle and lysine biosynthesis. Of interest for research on mitochondrial metabolite transporters.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Pyroglutamic Acid United States Pharmacopeia (USP) Reference Standard

USP

1589029

Pyroglutamic Acid

L Palmieri et al.
The Journal of biological chemistry, 276(3), 1916-1922 (2000-10-03)
The nuclear genome of Saccharomyces cerevisiae encodes 35 members of a family of membrane proteins. Known members transport substrates and products across the inner membranes of mitochondria. We have localized two hitherto unidentified family members, Odc1p and Odc2p, to the
Normal kynurenine metabolism in 2-oxoadipic aciduria.
A C Sewell et al.
Journal of inherited metabolic disease, 22(8), 949-950 (1999-12-22)
R Lukacin et al.
European journal of biochemistry, 249(3), 748-757 (1997-12-12)
Flavanone 3beta-hydroxylase, involved in the biosynthesis of flavonoids, catechins, and anthocyanidins, is a non-heme iron enzyme, dependent on Fe2+, molecular oxygen, 2-oxoglutarate, and ascorbate, the typical cofactors of the class of 2-oxoglutarate-dependent dioxygenases. Sequence alignment analysis of various 2-oxoglutarate-dependent dioxygenases
S A Osmani et al.
European journal of biochemistry, 147(1), 119-128 (1985-02-15)
Cell-free extracts of Rhizopus arrhizus contain exclusively cytosolic pyruvate carboxylase and NAD-glutamate dehydrogenase, a single mitochondrial isoenzyme of NADP-isocitrate dehydrogenase, and both mitochondrial and cytosolic isoenzymes of NADP-malate dehydrogenase (decarboxylating). Other enzymes examined have sub-cellular localisations similar to those characteristic
Iwona Gabriel et al.
FEMS yeast research, 13(2), 143-155 (2012-10-31)
The LYS12 gene from Candida albicans, coding for homoisocitrate dehydrogenase was cloned and expressed as a His-tagged protein in Escherichia coli. The purified gene product catalyzes the Mg(2+)- and K(+)-dependent oxidative decarboxylation of homoisocitrate to α-ketoadipate. The recombinant enzyme demonstrates

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