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86614

Tetraethylammonium chloride

BioUltra, Molecular Biology, ≥99.0% (AT)

Synonym(s):

Etamon chloride, TEAC, TEA chloride

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About This Item

Linear Formula:
(C2H5)4N(Cl)
CAS Number:
56-34-8
Molecular Weight:
165.70
UNSPSC Code:
12352107
NACRES:
NA.26
PubChem Substance ID:
57653171
EC Number:
200-267-5
Beilstein/REAXYS Number:
3563247
MDL number:
MFCD00011828

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InChI key

YMBCJWGVCUEGHA-UHFFFAOYSA-M

InChI

1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1

SMILES string

[Cl-].CC[N+](CC)(CC)CC

grade

Molecular Biology

product line

BioUltra

assay

≥99.0% (AT)

form

powder

mol wt

165.70 g/mol

technique(s)

gas chromatography (GC): suitable

impurities

DNases, none detected, RNases, none detected, insoluble matter, passes filter test, phosphatases, none detected, proteases, none detected

solubility

H2O: 1 M at 20 °C, clear, colorless

anion traces

bromide (Br-): ≤500 mg/kg, sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg, As: ≤0.1 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg

λ

1 M in H2O

UV absorption

λ: 260 nm Amax: 0.03, λ: 280 nm Amax: 0.03

Quality Level

100

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1 of 4

This Item
T22658661674202
Tetraethylammonium chloride BioUltra, Molecular Biology, ≥99.0% (AT)

Sigma-Aldrich

86614

Tetraethylammonium chloride

Tetraethylammonium chloride ≥98% (titration)

Sigma-Aldrich

T2265

Tetraethylammonium chloride

Tetraethylammonium chloride for electrochemical analysis, ≥99.0%

Supelco

86616

Tetraethylammonium chloride

Tetramethylammonium chloride suitable for ion pair chromatography, LiChropur™, ≥99.0% (AT)

Supelco

74202

Tetramethylammonium chloride

assay

≥99.0% (AT)

assay

≥98% (titration)

assay

≥99.0% (AT)

assay

≥99.0% (AT)

form

powder

form

powder

form

crystals

form

crystals

grade

for molecular biology

grade

-

grade

for electrochemical analysis

grade

-

technique(s)

gas chromatography (GC): suitable

technique(s)

blocking: suitable

technique(s)

-

technique(s)

ion pair chromatography: suitable

solubility

H2O: 1 M at 20 °C, clear, colorless

solubility

-

solubility

methanol: 0.1 g/mL, clear, colorless

solubility

-

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

General description

Tetraethylammonium (TEA), a simple quaternary ammonium compound, is commonly used to block potassium channels. It can physically enter the pore and block the channel. Additionally, TEA either imitates or antagonizes the actions of choline and acetylcholine, two other quaternary ammonium ions.[1]

Application

Tetraethylammonium chloride has been used:

  • as a pharmacological agent in electrophysiology to study its pharmacological effects on Cnidarians[2]
  • as a component in refolding buffer for protein refolding[3]
  • to puff onto isolated patches to block voltage-gated K+ (Kv3) channels and post-hoc evaluation[4]

Features and Benefits

  • Assay: ≥99.0% (AT), BioUltra, for molecular biology
  • Suitable for gas chromatography (GC)

Other Notes

TEACl method of DNA-DNA hybridization[5]

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

201.2 °F - closed cup

flash_point_c

94 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP1795
BCCM1161
BCCH5988
BCCF0377
BCCB7161

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Viktor J Olah et al.
eLife, 11 (2022-06-22)
In Alzheimer's disease (AD), a multitude of genetic risk factors and early biomarkers are known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD remain controversial. Toxic plaques and tangles correlate with progressive neuropathology, yet disruptions in circuit
Tetraethylammonium
Simmons MA
xPharm: The Comprehensive Pharmacology Reference, 1-3 (2007)
Avinash Jaiganesh et al.
Structure (London, England : 1993), 26(9), 1210-1225 (2018-07-24)
Cadherin-23 (CDH23) is an essential component of hair-cell tip links, fine filaments that mediate inner-ear mechanotransduction. The extracellular domain of CDH23 forms about three-fourths of the tip link with 27 extracellular cadherin (EC) repeats that are structurally similar but not
A. Caccone et al.
NATO ASI Ser., Ser H, 57, 385-385 (1991)
Timothy S Balmer et al.
eLife, 10 (2021-02-23)
Synapses of glutamatergic mossy fibers (MFs) onto cerebellar unipolar brush cells (UBCs) generate slow excitatory (ON) or inhibitory (OFF) postsynaptic responses dependent on the complement of glutamate receptors expressed on the UBC's large dendritic brush. Using mouse brain slice recording
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