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902H-0

Cytokeratin 5 & 6 (D5/16B4) + TTF-1 (8G7G3/1) Mouse Monoclonal Antibody

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
D5&16B4 + 8G7G3/1, monoclonal
Application:
—
Citations:
9

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

D5&16B4 + 8G7G3/1, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

bottle of 1.0 mL predilute (902H-07), bottle of 7.0 mL predilute (902H-08)

isotype

IgG1

shipped in

wet ice

storage temp.

2-8°C

Quality Level

100, 500

Gene Information

human ... KRT5(3852)

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This Item
356M-1356R-1335M-9
Cytokeratin 5 & 6 (D5/16B4) + TTF-1 (8G7G3/1) Mouse Monoclonal Antibody

Sigma-Aldrich

902H-0

Cytokeratin 5 & 6 (D5/16B4) + TTF-1 (8G7G3/1) Mouse Monoclonal Antibody

Cytokeratin 5 & 6 (D5 & 16B4) Mouse Monoclonal Antibody

Sigma-Aldrich

356M-1

Cytokeratin 5 & 6 (D5 & 16B4) Mouse Monoclonal Antibody

Cytokeratin 5 & 6 (EP24 & EP67) Rabbit Monoclonal Primary Antibody

Sigma-Aldrich

356R-1

Cytokeratin 5 & 6 (EP24 & EP67) Rabbit Monoclonal Primary Antibody

Cytokeratin (35betaH11) Mouse Monoclonal Antibody

Sigma-Aldrich

335M-9

Cytokeratin (35betaH11) Mouse Monoclonal Antibody

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

biological source

mouse

biological source

mouse

biological source

rabbit

biological source

mouse

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

clone

D5&16B4 + 8G7G3/1, monoclonal

clone

D5 & 16B4, monoclonal

clone

EP24 & EP67, monoclonal

clone

35betaH11, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

General description

Anti-Cytokeratin 5 & 6 labels greater than 90% of Eptihelioid Mesotheliomas. Anti-Cytokeratin 5 & 6 stains the cytoplasm of such cells. Anti-TTF-1 stains the nuclei in the case of lung adenocarcinomas and is negative in nearly all mesotheliomas. When the differential diagnosis seeks to distinguish between mesothelioma and adenocarcinoma of the lung, the nuclear vs. Cytoplasmic staining pattern of this cocktail can be of significant value in making the diagnosis.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note


IVD
IVD
IVD
RUO

Other Notes

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Certificates of Analysis (COA)

Lot/Batch Number
0000398092
0000357559
0000357559
0000398092
0000207190

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Pablo A Bejarano et al.
Archives of pathology & laboratory medicine, 127(2), 193-195 (2003-02-04)
The immunohistochemical identification of thyroid transcription factor-1 (TTF-1) is regarded as the presence of a nuclear pattern of staining and is used to identify tumors of thyroid or pulmonary origin. Although there have been reports of cytoplasmic expression of TTF-1
Dongfeng Tan et al.
Human pathology, 34(6), 597-604 (2003-06-27)
Thyroid transcription factor 1 (TTF-1), a homeodomain-containing transcription factor, plays a pivotal role in lung development, cell growth, and differentiation processes. The current literature reports considerable variation in frequency of TTF-1 protein expression in human non-small cell lung cancer (NSCLC).
P M Cury et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 13(2), 107-112 (2000-03-04)
Until recently, the standard approach of most laboratories in distinguishing epithelioid pleural mesothelioma from metastatic adenocarcinoma has been a negative result from a panel of adenocarcinoma-associated antibodies. However, several "mesothelium-associated" antibodies have been proposed as useful in this situation, and
M Srodon et al.
Human pathology, 33(6), 642-645 (2002-08-02)
Metastatic carcinoma of unknown primary origin is a perplexing but common problem, accounting for up to 10% to 15% of all solid tumors at presentation. Many of these metastases presumably arise from primary lung carcinomas, but the morphologic features and
K Y Jang et al.
Analytical and quantitative cytology and histology, 23(6), 400-404 (2002-01-05)
To estimate the utility of thyroid transcription factor-1 (TTF-1) and the combined cytokeratin 7 (CK7) and 20 (CK20) immunoprofile as a marker for identifying the primary site of metastatic adenocarcinoma in effusions of the serous cavity. Formalin-fixed, paraffin-embedded cell block
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