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904H-0

Sigma-Aldrich

HMB-45 + MART-1 (Melan A) (A103) + Tyrosinase (T311) Mouse Monoclonal Antibody

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NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

HMB-45+A103+T311, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

bottle of 1.0 mL predilute (904H-07)
bottle of 7.0 mL predilute (904H-08)

manufacturer/tradename

Cell Marque™

isotype

IgG1κ
IgG1
IgG2a

shipped in

wet ice

storage temp.

2-8°C

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This Item
903H-0281M-9281M-8
HMB-45 + MART-1 (Melan A) (A103) + Tyrosinase (T311) Mouse Monoclonal Antibody

Sigma-Aldrich

904H-0

HMB-45 + MART-1 (Melan A) (A103) + Tyrosinase (T311) Mouse Monoclonal Antibody

MART-1 (M2-7C10) + Tyrosinase (T311) Mouse Monoclonal Antibody

Sigma-Aldrich

903H-0

MART-1 (M2-7C10) + Tyrosinase (T311) Mouse Monoclonal Antibody

MART-1 (Melan A) (M2-7C10) Mouse Monoclonal Antibody

Sigma-Aldrich

281M-9

MART-1 (Melan A) (M2-7C10) Mouse Monoclonal Antibody

MART-1 (Melan A) (A103) Mouse Monoclonal Antibody

Sigma-Aldrich

281M-8

MART-1 (Melan A) (A103) Mouse Monoclonal Antibody

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

clone

HMB-45+A103+T311, monoclonal

clone

M2-7C10 + T311, monoclonal

clone

M2-7C10, monoclonal

clone

A103, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

General description

Anti-HMB-45 identifies immature melanosomes. It shows greater specificity for malignant melanomas and metastatic melanomas. MART-1 (also known as Melan A) is a melanocyte differentiation antigen. It is present in melanocytes of normal skin and retina, nevi and in more than 85% of melanomas. Tyrosinase is an enzyme integral in the process of melanin synthesis, and found in 85% to 90% of malignant melanomas. Given these statistics, this cocktail is ideally suited to detection of melanomas and melanocytic lesions.

Quality


IVD
IVD
IVD
RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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T J de Vries et al.
The Journal of pathology, 193(1), 13-20 (2001-02-13)
With the recent availability of novel antibodies against melanoma antigens tyrosinase and MART-1, it is important to validate their usefulness in pathology practice and in screening patients for immunotherapy treatment. In the present study conducted by the Melanoma Cooperative Group
L Vaggelli et al.
Tumori, 86(4), 346-348 (2000-10-04)
Elective lymph node dissection (ELND) for patients with malignant melanoma is still controversial. A possible alternative could be biopsy of the first tumor draining lymph node, the sentinel node (SN), which can be identified by means of radionuclide techniques. Our
Deepali Gupta et al.
The American journal of surgical pathology, 26(11), 1450-1457 (2002-11-01)
Malignant melanomas of the vagina are rare tumors. In this study we present the clinicopathologic features and immunohistochemical analysis of 26 such cases seen in our institution over a period of 30 years. The patients' age ranged from 38 to
Guy Orchard
British journal of biomedical science, 59(4), 196-202 (2003-02-08)
Incidence of malignant melanoma (MM) is rising rapidly throughout the Western world, and the number of melanocytic lesions removed for histological assessment has increased. MM can present with a myriad of histological appearances that make diagnosis problematic, particularly when dealing
Vinod B Shidham et al.
BMC cancer, 3, 15-15 (2003-05-09)
MART-1, Melan-A, and Tyrosinase have shown encouraging results for evaluation of melanoma micrometastases in sentinel lymph nodes, as compared to conventionally used S-100 protein and HMB-45. To achieve higher sensitivity, some studies recommend evaluation of three sections, each at intervals
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Immunohistochemistry (IHC) techniques and applications have greatly improved, dermatopathology is still largely based on H&E stained slides.This paper outlines ways in which IHC antibodies can be utilized for dermatopathology.

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