Skip to Content
MilliporeSigma
All Photos(1)

Documents

91211

Sigma-Aldrich

Oxyresveratrol

≥97.0% (HPLC)

Synonym(s):

(E)-2,3′,4,5′-Stilbenetetrol, 2,3′,4,5′-Tetrahydroxy-trans-stilbene, 4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C14H12O4
CAS Number:
Molecular Weight:
244.24
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.25

Quality Level

assay

≥97.0% (HPLC)

form

solid

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

SMILES string

Oc1ccc(\C=C\c2cc(O)cc(O)c2)c(O)c1

InChI

1S/C14H12O4/c15-11-4-3-10(14(18)8-11)2-1-9-5-12(16)7-13(17)6-9/h1-8,15-18H/b2-1+

InChI key

PDHAOJSHSJQANO-OWOJBTEDSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Oxyresveratrol (OXY or ORV) is a naturally occurring polyphenolic stilbene that is predominantly present in the heartwood of many plants. It is primarily extracted from Artocarpus lakoocha Roxb. plant, and is one of the main constituents of this plant. ORV has a very simple chemical structure with a trans-1,2-diphenylethylene in its core and two hydroxyls (OH) groups attached to each aromatic ring.

Application

Oxyresveratrol has been used:
  • with poly(lactic-co-glycolic acid) (PLGA) nanoparticles to test its antioxidant effects and to investigate its role in the inhibition of superoxide anion (O2-) generation
  • to test its effects as an anti-neuroinflammatory agent on interleukin-1 beta (IL-1β)-induced HMC3 human microglial cell line
  • as a reference standard to determine its existence in Artocarpus lakoocha Roxb. (AL) extract using high-performance liquid chromatography (HPLC)

Biochem/physiol Actions

Oxyresveratrol is well-known due to its diverse biological and pharmacological properties. It is a potent antioxidant and anti-inflammatory agent. ORV also exerts neuroprotective activities and protects against cerebral ischemia, stroke, and several neurodegenerative disorders. It also displays anti-cancer, antimicrobial, hepatoprotective properties and protects against several other metabolic disorders. It is also a potent tyrosinase inhibitor.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

CorrosionExclamation mark

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 10

1 of 10

trans-Polydatin phyproof® Reference Substance

PHL89312

trans-Polydatin

Polydatin United States Pharmacopeia (USP) Reference Standard

USP

1546194

Polydatin

Resveratrol European Pharmacopoeia (EP) Reference Standard

Y0001194

Resveratrol

Resveratrol analytical standard

Supelco

34092

Resveratrol

Viniferin ≥95% (LC/MS-ELSD)

Sigma-Aldrich

SMB00074

Viniferin

trans-Resveratrol United States Pharmacopeia (USP) Reference Standard

USP

1602105

trans-Resveratrol

(±)-Naringenin ≥95%

Sigma-Aldrich

N5893

(±)-Naringenin

Oleanolic acid ≥97%

Sigma-Aldrich

O5504

Oleanolic acid

Morin hydrate powder

Sigma-Aldrich

M4008

Morin hydrate

Dasatinib ≥98% (HPLC)

Sigma-Aldrich

SML2589

Dasatinib

Yi-Ching Chen et al.
BMC complementary and alternative medicine, 13, 45-45 (2013-02-26)
Morus alba has long been used in traditional Chinese medicine to treat inflammatory diseases; however, the scientific basis for such usage and the mechanism of action are not well understood. This study investigated the action of M. alba on leukocyte
Shaida A Andrabi et al.
Brain research, 1017(1-2), 98-107 (2004-07-21)
Oxidative stress is one of the major pathological factors in the cascade that leads to cell death in cerebral ischemia. Here, we investigated the neuroprotective effect of a naturally occurring antioxidant, oxyresveratrol, to reduce brain injury after cerebral stroke. We
Jin Hee Choi et al.
International journal of molecular sciences, 20(1) (2018-12-24)
The phytochemical oxyresveratrol has been shown to exert diverse biological activities including prevention of obesity. However, the exact reason underlying the anti-obese effects of oxyresveratrol is not fully understood. Here, we investigated the effects and mechanism of oxyresveratrol in adipocytes
Hai-Shu Lin et al.
Biomedical chromatography : BMC, 24(12), 1373-1378 (2010-11-16)
A rapid HPLC method was developed and validated for the quantification of oxyresveratrol analog trans-2,4,3',5'-tetramethoxystilbene (oxyresveratrol tetramethyl ether, OTE) in rat plasma. Chromatographic separation was achieved on an RP-HPLC column, which was protected by a guard column through a 12 min
N H Shin et al.
Biochemical and biophysical research communications, 243(3), 801-803 (1998-03-17)
Oxyresveratrol (2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibited a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis. Oxyresveratrol with 0.3 to 5 microM exhibited potent and dose-dependent

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service