This product is not tested for RNase activity. Currently, an RNAse tested PMSF product is not available.
93482
Phenylmethanesulfonyl fluoride solution
~0.1 M in ethanol (T)
Synonym(s):
Benzylsulfonyl fluoride, PMSF
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50 ML
$160.00
250 ML
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Available to ship onNovember 04, 2025Details
About This Item
CAS Number:
Beilstein/REAXYS Number:
2088311
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
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biological source
microbial
synthetic
Quality Level
form
liquid
concentration
~0.1 M in ethanol (T)
density
0.797 g/mL at 20 °C
storage temp.
2-8°C
SMILES string
FS(=O)(=O)Cc1ccccc1
InChI
1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChI key
YBYRMVIVWMBXKQ-UHFFFAOYSA-N
1 of 4
This Item | 78830 | 77004 | P7626 |
|---|---|---|---|
| biological source microbial, synthetic | biological source synthetic | biological source - | biological source synthetic |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 300 |
| form liquid | form powder or crystals | form solution | form powder |
| storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C | storage temp. - |
| concentration ~0.1 M in ethanol (T) | concentration - | concentration ~50% in acetonitrile | concentration - |
| density 0.797 g/mL at 20 °C | density - | density - | density - |
Application
Biochem/physiol Actions
Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.[4]
Phenylmethanesulfonyl fluoride (PMSF) is a serine protease inhibitor. It binds covalently to active site residue of proteases and prevents proteolytic activity. PMSF is used in cell lysate buffers during protein purification to prevent target protein degradation.[5] PMSF effectively inhibits the naloxone-precipitated withdrawal jumping.[6]
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2
Storage Class
3 - Flammable liquids
wgk_germany
WGK 2
flash_point_f
53.6 °F - closed cup
flash_point_c
12 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Metzis V, et al.
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SREBP1 drives KRT80-dependent cytoskeletal changes and invasive behavior in endocrine resistant ERalpha breast cancer
Magnani L, et al.
bioRxiv, 380634-380634 (2018)
DNA-encoded library-derived DDR1 inhibitor prevents fibrosis and renal function loss in a genetic mouse model of Alport syndrome
Richter H, et al.
ACS Chemical Biology (2018)
Arwin J Brouwer et al.
Bioorganic & medicinal chemistry, 19(7), 2397-2406 (2011-03-23)
We have designed and synthesized novel irreversible serine protease inhibitors containing aliphatic sulfonyl fluorides as an electrophilic trap. These substituted taurine sulfonyl fluorides derived from taurine or protected amino acids were conveniently synthesized from β-aminoethanesulfonyl chlorides using KF/18-crown-6 or from
Jih-Jung Chen et al.
Journal of natural products, 71(1), 71-75 (2008-01-01)
Two new benzoic acid derivatives, (E)-3-acetyl-6-(3,7-dimethylocta-2,6-dienyloxy)-2,4-dihydroxybenzoic acid (1) and (E)-3-acetyl-4-(3,7-dimethylocta-2,6-dienyloxy)-2,6-dihydroxybenzoic acid (2), and three new acetophenones, (E)-1-(5-(3,7-dimethylocta-2,6-dienyloxy)-7-hydroxy-2,2-dimethyl-2 H-chromen-8-yl)ethanone (3), (E)-1-(5-(3,7-dimethylocta-2,6-dienyloxy)-7-hydroxy-2-methyl-2-(4-methylpent-3-enyl)-2 H-chromen-8-yl)ethanone (4), and (R,E)-1-(5-(3,7-dimethylocta-2,6-dienyloxy)-3,7-dihydroxy-2,2-dimethylchroman-8-yl)ethanone (5), have been isolated from the fruits of Melicope semecarpifolia, together with eight known compounds. The
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Is this product 93482 RNase-free?
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How can I further dilute Product 93482, Phenylmethanesulfonyl fluoride solution?
1 answer-
We would recommend that you use an anhydrous ethanol to further dilute this solution, since PMSF is very unstable in water.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What can Product 93482, Phenylmethanesulfonyl fluoride solution, be used for?
1 answer-
PMSF is a serine protease inhibitor, inhibiting the activity of enzymes such as thrombin, trypsin, papain, chymotrypsin and proteinase K. It also inhibits mammalian acetylcholinesterases.
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