95209

Sigma-Aldrich

L-Ascorbic acid

BioUltra, ≥99.5% (RT)

Synonym(s):
Antiscorbutic factor, Vitamin C, L-Threoascorbic acid
Empirical Formula (Hill Notation):
C6H8O6
CAS Number:
Molecular Weight:
176.12
Beilstein/REAXYS Number:
84272
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.79

Quality Level

biological source

synthetic

product line

BioUltra

assay

≥99.5% (RT)

form

powder or crystals

impurities

insoluble matter, passes filter test

ign. residue

≤0.05% (as SO4)

loss

≤0.05% loss on drying, 20 °C (HV)

color

colorless

pH

1.0-2.5 (25 °C, 1 M in H2O)

mp

190-194 °C (dec.)

solubility

H2O: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤20 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

absorption

cut-off at 306 nm in H2O at 1 M

SMILES string

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

InChI key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

Gene Information

human ... SLC23A2(9962)

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General description

L-Ascorbic acid, also known as vitamin C, is a water-soluble vitamin. It is naturally present in a variety of foods such as citrus fruits and vegetables. It is present only in minimal amount in milk.

Application

L-Ascorbic acid has been used as an antioxidant supplement in incubation solution for dissected and sliced brain sections. It has also been used as a supplement in phosphate-buffered saline (PBS) wash buffer during oxidative GFP chromophore formation.

Biochem/physiol Actions

L-Ascorbic acid (Vitamin C) acts as a potential anti-oxidant and reducing agent. It prevents bacterial mutagenesis induced by N-nitroso compounds. In plants, vitamin C elicits several cellular processes such as growth, apoptosis, pathogen responses, hormone responses, flowering and senescence, and protection against environmental stresses. Vitamin C deficiency is associated with the development of scurvy, prominent - gingivitis, perifollicular hemorrhages, poor wound healing, petechiae and ecchymosis.

Other Notes

Denaturation of proteins; Dimeric association of E. coli RNA polymerase α subunits, studied by cleavage of single cysteine α subunits conjugated to Fe-BABE.

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Calcium Imaging Techniques In Vitro to Explore the Role of Dendrites in Signaling Physiological Action Potential Patterns
Neuromethods, 165-187 (2012)
F C Brown et al.
Neurochemical research, 3(3), 357-366 (1978-06-01)
Under conditions that are optimum for DbetaH, ascorbic acid denatures serum albumin, gamma-globulin, catalase, and DbetaH. With ascrobate plus Cu2+, the proteins are almost completely destroyed. Pyrazole protects DbetaH and albumin, but not catalase. Superoxide dismutase (SOD) is not denatured...
Calcium Imaging Techniques In Vitro to Explore the Role of Dendrites in Signaling Physiological Action Potential Patterns
Bonnan A, et al.
The Journal of applied nutrition (1953)
R Miyake et al.
Biochemistry, 37(5), 1344-1349 (1998-03-07)
Proximity relationships between the two associated monomers of the Escherichia coli RNA polymerase alpha subunit were studied using a set of four mutant alpha subunits, each with a single Cys residue at one of the naturally occurring positions (54, 131...
The use of vitamin C as an antibiotic
Klenner FR
The Journal of applied nutrition, 6(6731), 274-278 (1953)

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