A1216

N-Acetyl-Ile-Glu-Thr-Asp-al

~99% (TLC), powder

• Synonym(s): Ac-IETD-CHO
• Empirical Formula (Hill Notation): C₂₁H₃₄N₄O₁₀
• CAS Number: 191338-86-0
• Molecular Weight: 502.52
• MDL number: MFCD01318858
• PubChem Substance ID: 329770688
• NACRES: NA.77

Properties

• biological source: synthetic
• Quality Level: 200
• Assay: ~99% (TLC)
• form: powder
• color: white
• solubility: H₂O: 1 mg/mL
• storage temp.: −20°C
• SMILES string: CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C=O
• InChI: 1S/C21H34N4O10/c1-5-10(2)17(22-12(4)28)20(34)24-14(6-7-15(29)30)19(33)25-18(11(3)27)21(35)23-13(9-26)8-16(31)32/h9-11,13-14,17-18,27H,5-8H2,1-4H3,(H,22,28)(H,23,35)(H,24,34)(H,25,33)(H,29,30)(H,31,32)/t10-,11+,13-,14-,17-,18-/m0/s1
• InChI key: AXTKTZHLZLOIIO-PBEPODTISA-N

Description

Biochem/physiol Actions

Caspase 8 inhibitor; blocks the cleavage of the 32 kDa caspase 3 precursor into the p12 and p20 subunits, thus blocking the formation of active caspase 3.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves