A1675

Sigma-Aldrich

Arg-Phe-Asp-Ser

≥97% (HPLC)

Empirical Formula (Hill Notation):
C22H33N7O8
CAS Number:
Molecular Weight:
523.54
MDL number:
PubChem Substance ID:

assay

≥97% (HPLC)

form

solid

storage temp.

−20°C

SMILES string

NC(CCCNC(N)=N)C(=O)NC(Cc1ccccc1)C(=O)NC(CC(O)=O)C(=O)NC(CO)C(O)=O

InChI

1S/C22H33N7O8/c23-13(7-4-8-26-22(24)25)18(33)27-14(9-12-5-2-1-3-6-12)19(34)28-15(10-17(31)32)20(35)29-16(11-30)21(36)37/h1-3,5-6,13-16,30H,4,7-11,23H2,(H,27,33)(H,28,34)(H,29,35)(H,31,32)(H,36,37)(H4,24,25,26)

InChI key

SAGYNNXCQOFQHW-UHFFFAOYSA-N

Biochem/physiol Actions

Blocks integrin-binding and nonbinding of fibronectin fragments

Other Notes

Peptide analog of Arg-Gly-Asp-Ser

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

3

Certificate of Analysis

Certificate of Origin

G A Homandberg et al.
Archives of biochemistry and biophysics, 310(1), 40-48 (1994-04-01)
We have reported that Fn fragments (Fn-f), which have been detected in synovial fluids of osteoarthritis and rheumatoid arthritis patients, can potently cause cartilage chondrolysis and depress proteoglycan (PG) synthesis in cartilage tissue cultured as explants. Amino-terminal 29-kDa, gelatin-binding 50-kDa...

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