A2641

Sigma-Aldrich

4-Aza-DL-leucine dihydrochloride

Synonym(s):
β-Dimethylamino-DL-alanine
Empirical Formula (Hill Notation):
C5H12N2O2 · 2HCl
CAS Number:
Molecular Weight:
205.08
MDL number:
PubChem Substance ID:

assay

≥98.0% (TLC)

form

powder

color

white to off-white

storage temp.

−20°C

SMILES string

OC(C(N)CN(C)C)=O.[H]Cl.[H]Cl

InChI

1S/C5H12N2O2.ClH/c1-7(2)3-4(6)5(8)9;/h4H,3,6H2,1-2H3,(H,8,9);1H

InChI key

JXAGRLBYOYAIRY-UHFFFAOYSA-N

Biochem/physiol Actions

4-Aza-DL-leucine is used as a leucine analogue that is toxic for bacterial high-affinity branched-chain amino acid (BCAA) transport system (LIV-I). 4-Aza-DL-leucine is used to select mutants of the LIV-1 transporter.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Azusa Saika et al.
AMB Express, 1(1), 6-6 (2011-09-13)
Ralstonia eutropha PHB-4 expressing Pseudomonas sp. 61-3 polyhydroxyalkanoate (PHA) synthase 1 (PhaC1Ps) synthesizes PHA copolymer containing 3-hydroxybutyrate (3HB) and a small amount (0.5 mol%) of 3-hydroxy-4-methylvalerate (3H4MV) from fructose as a carbon source. In this study, enhanced incorporation of 3H4MV...
Feng Wang et al.
Journal of bacteriology, 191(8), 2574-2584 (2009-02-10)
Members of the genus Shewanella inhabit various environments; they are capable of synthesizing various types of low-melting-point fatty acids, including monounsaturated fatty acids (MUFA) and branched-chain fatty acids (BCFA) with and without eicosapentanoic acid (EPA). The genes involved in fatty...
T Hoshino et al.
Journal of bacteriology, 172(10), 5540-5543 (1990-10-01)
About 30 mutants of Pseudomonas aeruginosa PAO defective in the high-affinity branched-chain amino acid transport system (LIV-I) were isolated by the selection for resistance to 4-aza-DL-leucine, a toxic leucine analog for LIV-I. All of the mutants were complemented by plasmid...
Haifeng Su et al.
Scientific reports, 6, 39543-39543 (2016-12-21)
Biosynthesis approaches for the production of higher alcohols as a source of alternative fossil fuels have garnered increasing interest recently. However, there is little information available in the literature about using undirected whole-cell mutagenesis (UWCM) in vivo to improve higher...
Takashi Koyanagi et al.
FEMS microbiology letters, 237(1), 73-77 (2004-07-23)
The growth of Escherichia coli is inhibited by an antibiotic compound, azaserine (O-diazoacetyl-L-serine). Previous studies revealed the biochemical properties of azaserine, which involves inhibition of various enzymatic reactions as well as introduction of DNA breakage. However, genetically, nothing has been...

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