C0662

Sigma-Aldrich

6-Carboxyfluorescein

~97% (HPLC)

Synonym(s):
FLUOS, 6-FAM
Empirical Formula (Hill Notation):
C21H12O7
CAS Number:
Molecular Weight:
376.32
Beilstein/REAXYS Number:
54341
MDL number:
PubChem Substance ID:
NACRES:
NA.47

Quality Level

assay

~97% (HPLC)

form

powder

application(s)

hematology: suitable
histology: suitable

mp

>300 °C (lit.)

solubility

0.1 M NaOH: 9.80-10.20 mg/mL, clear to slightly hazy, orange

λmax

492 nm at 0.1 N in NaOH

fluorescence

λex 492 nm; λem 517 nm (pH 8.0)

Featured Industry

Diagnostic Assay Manufacturing

storage temp.

2-8°C

SMILES string

OC(=O)c1ccc2C(=O)OC3(c4ccc(O)cc4Oc5cc(O)ccc35)c2c1

InChI

1S/C21H12O7/c22-11-2-5-14-17(8-11)27-18-9-12(23)3-6-15(18)21(14)16-7-10(19(24)25)1-4-13(16)20(26)28-21/h1-9,22-23H,(H,24,25)

InChI key

BZTDTCNHAFUJOG-UHFFFAOYSA-N

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Application

6-Carboxyfluorescein has been used to check the plasma membrane integrity in sperm cells.
Fluorescent dye.

Packaging

50 mg in poly bottle

Biochem/physiol Actions

6-Carboxyfluorescein diacetate is a membrane permeable compound. It can be hydrolysed by intracellular esterases to form a membrane impermeable bright green fluorescent molecule, 6-carboxyfluorescein.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Przemysław Płociński et al.
Nature communications, 8(1), 1251-1251 (2017-11-02)
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Food and environmental virology, 11(3), 274-287 (2019-05-16)
Monitoring of environmental water is crucial to protecting humans and animals from possible health risks. Although numerous human-specific viral markers have been designed to track the presence of human fecal contamination in water, they lack adequate sensitivity and specificity in...
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Comparison of efficiency between two artificial insemination methods using frozen-thawed semen in domestic cat (Felis catus): artificial insemination in domestic cats.
Villaverde AI, et al.
Animal Reproduction Science, 114, 434-434 (2009)
Stephanie Pfaender et al.
Hepatology (Baltimore, Md.), 61(2), 447-459 (2014-09-13)
Hepatitis C virus (HCV) has a very narrow species and tissue tropism and efficiently replicates only in humans and the chimpanzee. Recently, several studies identified close relatives to HCV in different animal species. Among these novel viruses, the nonprimate hepaciviruses...

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