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C153

Sigma-Aldrich

Cyprodime hydrobromide

>96%, solid

Synonym(s):
(–)-N-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one hydrobromide
Empirical Formula (Hill Notation):
C22H29NO3 · HBr
CAS Number:
Molecular Weight:
436.38
MDL number:
PubChem Substance ID:

assay

>96%

form

solid

optical activity

[α]20/D −82.9°, c = 1.03 in 95% ethanol(lit.)

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 12 mg/mL
H2O: insoluble
ethanol: soluble

SMILES string

Br.COc1cccc2C[C@H]3N(CC[C@@]4(CC(=O)CC[C@@]34OC)c12)CC5CC5

Biochem/physiol Actions

Selective μ opioid receptor antagonist.

Caution

Photosensitive

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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More Documents

Quotes and Ordering

Mariana Spetea et al.
Journal of medicinal chemistry, 47(12), 3242-3247 (2004-05-28)
The synthesis, biological, and pharmacological evaluation of novel derivatives of cyprodime are described. Their binding affinities at mu, delta, and kappa opioid receptors were evaluated using receptor binding assay. It was observed that the affinity of these compounds was sensitive
H C Jackson et al.
Psychopharmacology, 111(4), 486-490 (1993-01-01)
This study investigates the possible involvement of opioid receptors in the action of a variety of anticonvulsant agents. The opioid antagonist naloxone (0.3, 1 mg/kg IP) and the selective mu-opioid antagonist cyprodime (3 mg/kg IP) significantly inhibited the increase in
S Józefowski et al.
Polish journal of pharmacology, 49(4), 229-237 (1997-08-01)
The head kidney is the main lymphopoietic organ of teleost fish. It is the source of leukocytes inhabiting the peritoneal cavity during an experimental peritoneal inflammation (Gruca et al., Folia Biol.-Kraków, 1997, 44, 137-142). The number of elicited peritoneal leukocytes
Wency Chen et al.
World journal of gastroenterology, 18(12), 1391-1396 (2012-04-12)
To investigate the role of opioid μ-receptor subtype in opiate-induced constipation (OIC). The effect of loperamide on intestinal transit was investigated in mice. Ileum strips were isolated from 12-wk-old male BALB/c mice for identification of isometric tension. The ileum strips
H Schmidhammer et al.
Journal of medicinal chemistry, 38(16), 3071-3077 (1995-08-04)
A series of 3-hydroxy-substituted analogues (3-7) of the mu selective opioid antagonist cyprodime has been synthesized in order to evaluate the role of a hydroxy group at C-3 concerning mu opioid antagonist selectivity. Compounds 3-7 were tested in bioassays (electrical

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