C2901

Sigma-Aldrich

Cholecystokinin (CCK) Fragment 26-33 Amide, Non-sulfated

≥95% (HPLC), powder

Synonym(s):
CCK-8, non-sulfated
Empirical Formula (Hill Notation):
C49H62N10O13S2
CAS Number:
Molecular Weight:
1063.21
MDL number:
PubChem Substance ID:
NACRES:
NA.32
Pricing and availability is not currently available.

Quality Level

assay

≥95% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)CC(O)=O)C(=O)NCC(=O)NC(Cc2c[nH]c3ccccc23)C(=O)NC(CCSC)C(=O)NC(CC(O)=O)C(=O)NC(Cc4ccccc4)C(N)=O

InChI

1S/C49H62N10O13S2/c1-73-18-16-34(55-47(70)37(21-28-12-14-30(60)15-13-28)58-44(67)32(50)23-41(62)63)45(68)53-26-40(61)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(71)56-35(17-19-74-2)46(69)59-39(24-42(64)65)49(72)57-36(43(51)66)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52,60H,16-24,26,50H2,1-2H3,(H2,51,66)(H,53,68)(H,54,61)(H,55,70)(H,56,71)(H,57,72)(H,58,67)(H,59,69)(H,62,63)(H,64,65)

InChI key

OIXQINQYMGNCII-UHFFFAOYSA-N

Gene Information

human ... CCK(885)

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Amino Acid Sequence

Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2

Application

Cholecystokinin (CCK) Fragment 26-33 Amide, Non-sulfated has been used in the specificity testing against gastrin and pepsinogen I proteins.

Biochem/physiol Actions

Biologically inactive form of CCK-8; CCKB/gastrin receptor agonist that has no activity at the CCKA receptor.
Cholecystokinin (CCK) is a 115 amino acid preprohormone and a neurotransmitter. It exists in many isoforms. The octapeptide of CCK (CCK-8S) is the most abundant form. CCK is mapped to human chromosome 3p22.1. CCK interacts with receptors of the gastrointestinal tract and nervous system. Polymorphisms in the CCK is implicated in hallucinations in patients with Parkinson′s disease. CCK plays a key role in the activation of the calcineurin-regulated nuclear factor of activated T-cells (NFATs).

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Genetic substrates of psychosis in patients with Parkinson's disease: a critical review.
Lenka A, et al.
Journal of the Neurological Sciences, 364(5), 33-41 (2016)
Advances in molecular genetics of panic disorder.
Maron E, et al.
Molecular Psychiatry, 15(7), 681-681 (2010)
Atrophic gastritis serum levels of amidated gastrin-17 and pepsinogen I in atrophic gastritis: an observational case-control study.
Sipponen P, et al.
Scandinavian Journal of Gastroenterology, 37(7), 785-791 (2002)
Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide γ.
Bowers ME, et al.
Physiology & Behavior, 107(5), 699-710 (2012)
Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo.
Gurda GT, et al.
Molecular Biology of the Cell, 19(1), 198-206 (2008)

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