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C3586

Sigma-Aldrich

4-Carboxy-3-hydroxy-L-phenylglycine

Synonym(s):
(S)-4C3H-PG
Empirical Formula (Hill Notation):
C9H9NO5
CAS Number:
Molecular Weight:
211.17
MDL number:

solubility

1 M NaOH: 0.211 mg/mL

SMILES string

N[C@H](C(O)=O)c1ccc(C(O)=O)c(O)c1

Biochem/physiol Actions

Metabotropic GluR2/3 glutamate receptor agonist and GluR1 glutamate receptor antagonist

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More documents

Quotes and Ordering

A E Kingston et al.
Neuropharmacology, 34(8), 887-894 (1995-08-01)
The antagonist effects of the 4-carboxyphenylglycines: (S)-4-carboxy-3hydroxyphenylglycine (4C3HPG), (S)-4-carboxyphenylglycine (4CPG) and (+)-alpha-methyl-4-carboxyphenylglycine (M4CPG) were compared on functional responses of human metabotropic glutamate receptor (mGluR) subtypes mGluR1 alpha and mGluR5a. These receptors both belong to group 1 type mGluRs which couple
M Pizzi et al.
Neuropharmacology, 39(5), 903-910 (2000-03-04)
Research has provided evidence about the role of excitotoxicity in the pathophysiology of sporadic amyotrophic lateral sclerosis and suggests that AMPA/kainate receptor activation contributes greatly in mediating glutamate injury to motor neurons. The recent finding of variable expression of metabotropic
E F Birse et al.
Neuroscience, 52(3), 481-488 (1993-02-01)
The possible roles of G-protein coupled metabotropic glutamate receptors in central nervous function are currently the focus of intensive investigation. The complexity of effects produced by agonists at these receptors probably reflects the activity of a range of sub-types. The

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